1. Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132:1497, 1960.

2. Deininger M, Goldman JM, Melo JV: The molecular biology of chronic myeloid leukemia. Blood 96:3343-3356, 2000.

3. Kralovics R, Passamonti F, Buser AS, et al.: A gain-of-function mutation of JAK2 myeloproliferative disorders. N Engl J Med 352:1779-1790, 2005.

4. Baxter EJ, Scott LM, Campbell PJ, et al.: Acquired mutation of the tyrosine kinase JAK2 in human myeloprolif-erative disorders. Lancet 365:1054-1061, 2005.

5. Levine RL, Wadleigh M, Cools J, et al.: Activating mutation in the tyrosine kinase JAK2 in polycythemia, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387-397, 2005.

6. Groffen J, Heisterkamp, N. The chimeric BCR-ABL gene. Baillière's Clin Hematol 10:187, 1997.

7. Mughal TI, Goldman JM: Chronic myeloid leukemia: current status and controversies. Oncology 18:837-854, 2004.

8. Morrison VA: Chronic leukemias. Cancer J Clin 44:353, 1994.

9. Muir CS, Waterhouse J, Mack T, Powell J, Whelan S: Cancer incidence in 5 continents, vol 5. IARC Scientific Publication no. 88. Lyon: International Agency for Research on Cancer, 1987.

Table 16.3 WHO classification of myelodysplastic/myeloproliferative diseases

Chronic myelomonocytic leukemia Atypical chronic myeloid leukemia Juvenile myelomonocytic leukemia Myelodysplastic/myeloproliferative disease, unclassifiable p23018; currently fewer than 100 patients with Ph-positive CNL have been reported worldwide. CNL affects older adults, compared to CML. It is of considerable interest that in about 20% of the reported cases, there was an associated malignancy, typically multiple myeloma, but none of these patients exhibited clonal-ity in their myeloid cells. Distinctions among chronic phase, accelerated phase, and blast crisis CML are discussed in Chapter 17.

10. Court Brown W, Abbatt J: Mortality from cancer causes after radiotherapy for ankylosing spondylitis. Br Med J 2:1327-1329, 1965.

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14. Eglin RP, Swann RA, Isaacs D, Moon ER: Chronic leukaemia in siblings. Lancet 2:984, 1984.

15. Posthuma EFM, Falkenburg JHF, Apperley JF, et al.: On behalf of the Chronic Leukemia Working Party of the EBMT. HLA-B8 and the HLA-A3 co expressed with HLA-B8 are associated with a reduced risk of the development of chronic myeloid leukemia. Blood 93:3863-3865, 1999.

16. Marmont A, et al.: Recurrence of PhMeukemia in donor cells after marrow transplantation for chronic granulo-cytic leukemia. N Engl J Med 31:990, 1988.

17. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001, pp. 15-60.

18. Melo JV: The diversity of the BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 96: 3343-3356, 2000.

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Chapter 17

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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