Restoration Of Fertility

Sperm quality may naturally improve after cancer treatment. However, some defects may persist. The incidence of infertility in men who have recovered sperm production following cytotoxic therapy is generally not higher than that of the general population. An interesting case report30 has documented paternity following bone marrow conditioning and transplantation in a patient with acute myeloid leukemia. For the first time, the preservation of fertile sperm was seen despite the use of chemotherapy. Cancer patients with sperm counts below normal (oligozoospermic) are still capable of having children.31 Similarly, infertile women who have menstrual dysfunction following cytotoxic therapy may be treated for menstrual dysfunction and infertility in a manner similar to that of the general population. However, the risk of an adverse pregnancy outcome is higher in these women, and they may require closer observation.32

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