Retroviral And Immunomodulatory Agents Retroviral monotherapy

Maintenance of viral DNA load can occur through either host genome replication or viral replication through the HTLV-1 reverse transcriptase.19 HTLV-1 replication can be inhibited by a variety of nucleoside reverse transcriptase inhibitors, including zidovudine, zalcitabine, tenofovir, and possibly, lamivudine.76,77 Zidovudine (AZT) is a thymidine analog, which after phosphorylation is incorporated into proviral DNA causing chain termination. It is unclear whether zidovudine monotherapy has significant activity.78

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