Sclerotic Bone Lesions

Conventional radiographs showed osteosclerotic lesions in 95% of our patients. Lytic lesions without evidence of sclerosis are rare. Approximately half of our patients had mixed sclerotic and lytic lesions. Forty-seven percent of our patients had only sclerotic lesions. A single solitary lesion was found in 45%, and the remainder had multiple lesions. The pelvis, spine, ribs, and proximal extremities are most often involved. In rare instances, multiple myeloma is associated with diffuse osteosclerotic bone lesions, and affected patients must be differentiated from those with POEMS syndrome.

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