Splenectomy And Natural History

Bouroncle19 reported on 105 patients followed with or without splenectomy, and noted a median survival of 5.8 years. Golomb et al.4 gave an update on 71 patients with a median survival, measured starting at the development of symptoms (not from diagnosis), of 70 months. Jansen and Hermans20 analyzed 391 patients from multiple institutions to evaluate the effectiveness of splenectomy, and noted an overall median survival of 48 months. Patients in this series, who underwent a splenectomy, had a survival benefit. The other observation from these reports was that several parameters had prognostic importance, including the degree of cytopenias and a history of infections.

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