Stem cell source

Pluripotent HSCs can be derived from bone marrow (BM) via numerous percutaneous aspirations or by leukapheresis of cells circulating in the blood following growth factor stimulation or recent chemotherapy, or both. Blood-derived stem cells appear to consistently shorten the time to neutrophil and platelet recovery, compared to BM. Peripheral blood cells have all but replaced bone marrow in general practice due to ease of collection, superior engraftment, and equiv-

alence of relapse risk and survival from comparison studies between the two approaches.12

0 0

Post a comment