For many years, a diagnosis of HCL was to be feared because of a shortened survival with multiple complications from infections, marked splenomegaly, and severe anemia and thrombocytopenia. Moreover, treatment options were limited, and often only supportive measures were available. Now in the twenty-first century we can list it along with the other triumphs in medical oncology, including Hodgkin's disease and tes-ticular carcinoma. The goals of treatment, to extend survival and improve the quality of life, have been reached.

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