Surgery is required to confirm the histologic diagnosis, but has no therapeutic role. The median survival of patients treated with supportive care alone is 1-3 months, compared to 4-5 months for those who undergo surgical resection.30 Furthermore, because PCNSL is often multifocal and deep within the brain, resection is technically difficult. Extensive surgery should be reserved for the occasional patient who requires urgent intervention because of acute neurologic deterioration due to cerebral herniation.

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