Tbi

0% at 100 days

2 year 55%

MRD, matched related donor; MMRD, mismatched related donor; URD: unrelated donor; TBI, total body irridiation; ATG, antithymocyte globulin

MRD, matched related donor; MMRD, mismatched related donor; URD: unrelated donor; TBI, total body irridiation; ATG, antithymocyte globulin with 6 complete responses and 3 partial responses. Six patients developed acute GvHD after DLI, and four patients progressed to chronic GvHD. This approach demonstrates that a significant GvM effect can be induced by the administration of DLI after transplant; however, its effect on overall outcome will require further follow-up. Ultimately, identifying the T cells mediating GvM and their target antigens will allow DLI with antigen-specific T cells to both enhance efficacy and avoid toxicity.

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