Time Trends

The incidence and mortality rates for MM were not available until 1950, when the disease was removed from the category of "lymphoreticular malignancies" and assigned a unique ICD code.5 The international trends in MM rates vary significantly from country to country. There was an overall increased incidence between 1970 and 1990 with a plateau in the last decade. The incidence and prevalence of MM in selected world population is shown in Table 80.1.26 This increase was attributed to underreporting in the earlier years and to improved diagnosis and more intensive surveys, especially in the elderly, in the later years (diagnostic phenomenon) rather than an actual increase in incidence.7

Multiple myeloma incidence, mortality, and prevalence worldwide
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