Topical Steroids

Although widely used, limited data are available regarding the use of topical steroids in early stage MF. In an investigational trial, 79 patients were treated daily with topical class I-III steroids.23 Thirty-two (63%) stage T1 patients and seven (25%) stage T2 patients achieved complete clearing. Thirteen patients (40%) with stage T1 and two patients (29%) with stage T2 relapsed; however, the median observation time was only 9 months. Reported side effects were minor skin irritation in 2 patients, reversible skin atrophy in 1 patient, and reversible depression of serum cortisol levels in 10 patients.

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