Total Skin Electron Beam Therapy

Recently published data of the therapeutic efficacy of total skin electron beam therapy (TSEB) from centers with extensive experience showed 40-98% complete remission rates among patients with stage IA and MF IB, with approximately 50% of patients with clinical stage IA and 25% of patients with clinical stage IB remaining in long-term remission.38 TSEB treatment in early stages remains controversial because of its potential toxicity. Side effects can be significant, and consist of erythema, edema, scaling, ulceration, and irreversible loss of skin adnexa. TSEB may be repeated for palliative effects, although at reduced doses. Adjuvant therapy including PUVA, photopheresis, and INF-a may improve the duration of response.

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