Toxicity

The major toxicity of DCF is related to profound immunosuppression with significant granulocytopenia, as well as CD4+ lymphopenia. Rates of severe neutrope-nia vary with the regimen used, but range from 26% up to 96%. Associated rates of infection range from 26% up to 53%. Although uncommon, treatment-related deaths have been reported in many of the published series. Additional common toxicities include dermatitis, nausea, and vomiting, and less common toxicities include lethargy, altered taste, paresthesias, and conjunctivitis. Although the immunosuppression appears prolonged, there is no evidence that this results in an increase in serious delayed infections or second malignancies.

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