Treatment Strategies In Adult

Treatment programs in adult ALL have evolved from the successful strategies employed in pediatric ALL and incorporate multiple active agents into complex regimen-specific sequential therapies. The goal of these doseintensive regimens is rapid cytoreduction with restoration of normal hematopoiesis; prevention of the emergence of drug-resistant subclones; prophylaxis of sanctuary sites such as the central nervous system (CNS); and eradication of persistent MRD with prolonged maintenance chemotherapy. Therapy is generally divided into several phases: induction, postremission consolidation or intensification, CNS prophylaxis, and maintenance therapy.

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