Unrelated Allogenic Stem Cell Transplantation

The survival rates in patients who undergo a matched unrelated stem cell transplantation of approximately 35% are by far less impressive than those performed from matched sibling donors.97 In one report from 1996, the OS was around 54%.99 Various methods, including modified conditioning regimens and T-cell depletion, have been used to improve results,100,101 but relatively little progress has been made in comparison to matched sibling donor transplantation.97 Most deaths occur due to GvHD, graft failure, and opportunistic infections. More recent results, and those obtained in children, are more favorable.102103

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