Unrelated Donors

Since only about 30-35% of patients needing a stem cell transplant have a suitably HLA-matched relative able to donate, the majority of patients need alternate donors. As indicated earlier, some additional patients can be transplanted with partially matched related donors with acceptable outcomes. Nevertheless, many patients do not have suitable related donors and seek unrelated donors. Over the years, a number of national and international donor registries have been set up to facilitate unrelated-donor transplants. There are currently more than 9 million prospective donors registered along with a significant number of stored cord blood units (CBU).

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