Variant follicular lymphomas

Primary cutaneous follicular lymphomas have been somewhat controversial, probably due to lack of consistent definition. Many studies, when adhering to WHO classification criteria, report a low percentage

(<30%) of cases harboring a t(14;18)(q32;q21) and also low rate of expression of bcl-2 protein, compared to nodal follicular lymphoma. These lymphomas are very indolent and have an excellent prognosis.23 Pediatric follicular lymphomas are also a peculiar subset of follicular lymphomas. Although histopathologic features are essentially identical to adult cases, those occurring in children are usually bcl-2 protein negative and lack a BCL2/IGH translo-cation.24

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