What If Hlamatched Donors Are Not Available

If related donors and matched unrelated donors are not available, one may choose to consider partially matched unrelated donors. As discussed earlier, mismatched unrelated donors have increased risk of severe complications and increased mortality. However, despite the increased risk, successful outcomes are observed. Transplantation in these cases may benefit from alternate donor sources, protocols designed to minimize the risk of increased complication rates, or selection of donors whose mismatches may elicit less severe immune responses.

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