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Changes in the bone marrow microenvironment

• Release of proteases

• Modulation of SOF-1 expression i

Blood

Figure 94.2 Model of hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. In this model, G-CSF-induced HPC mobilization occurs in two steps. In the first step, G-CSF activates a target cell population (as yet undefined). The second step is the generation of secondary signals by these activated cells, leading in turn to HPC mobilization. Potential secondary signals include protease release by activated cells and the modulation of stromal-derived factor-1 (SDF-1) expression in the BM. (From Thomas et al.16, used with permission.)

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