Zap70 Expression In Cll B Lymphocytes

CLL patients whose leukemic lymphocytes do not have ZAP-70 positivity have been reported to have strong correlation with mutated VH status.67 However, we have not yet allowed introduction of ZAP-70 in clinical practice, and in decision-making for initiation of therapy, because other laboratories have found testing for ZAP-70 difficult to reproduce from one time to the next. Until the issues of correct methodology and predictable reproducibility of results have been resolved, we consider it premature to incorporate this test for making a decision if therapeutic intervention is appropriate.

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