History Of Mononuclear Cell Infiltration In Cancer

Mononuclear cell infiltration is a common feature of many types of human cancers. In fact, its occurrence is considered so unremarkable that there are no systematic studies describing the prevalence or intensity of infiltrates by tumor type or stage. Instead, it is generally asserted that intense infiltrates are associated with certain tumor types, such as medullary carcinoma of the breast and malignant melanoma (1,2), and that most other cancers are also infiltrated to differing extents. Even...

Genes In Melanoma

Regulation of Expression of MGSA GRO Genes in Melanocytic Cells The expression of chemokines is normally tightly regulated and is only transiently induced in response to mediators of the inflammatory response such as IL-1, tumor necrosis factor-a (TNF-a), and a variety of other agents (3). Interestingly, during tumor progression and chronic inflammation, this tight regulation of chemokine expression is disturbed such that numerous tumor lesions and chronically inflammed tissues have been...

Influence Melanoma Tumor Progression

In addition to the effects of C-X-C chemokines on leukocyte chemotaxis, the C-X-C chemokines MGSA GRO-a and IL-8 are reported to enhance the growth of normal melanocytes, nevocytes, and melanoma cells (4,5,7,15,44a). The expression of MGSA GRO or IL-8 in immortalized melanocytes is also associated with an enhanced ability to form colonies in soft agar and tumors in nude mice (5,16,47,48). IL-8 expression has also been correlated with an enhanced metastatic capacity for melanoma tumors (52)....

Pylori A Type I Carcinogen

Several diverse malignancies are known to arise from a background of chronic inflammation. Cholangiocarcinoma and bladder cancer are strongly associated with infection with the Digeneans Opisthorchis sinensis and Schistosoma haematobium. The viral infections hepatitis B and C and human papillomavirus have been causally linked with hepatocellular carcinoma and cervical carcinoma. H. pylori is the first bacterium to be linked with the development of human neoplasia. Prospective epidemiologic...

References

Chao, J. L. Vigne, E. D. Schriock, and R. N. Taylor. 1997. Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells. J. Clin. Endocrinol. Metab. 82 1621-1628. 2. Tortolero-Luna, G., and M. F. Mitchell. 1995. The epidemiology of ovarian cancer. J. Cell. Biochem. 23 Suppl. 200-207. 3. Parham, G., J. L. Phillips, M. L. Hicks, N. Andrews, W. B. Jones, H. M. Shingleton, and H. R. Menck. 1997. The National...