Vinca Alkaloids

-vinblastine, vincristine, vinorelbine Treatment 1. 150 units hyaluronidase reconstituted in 1-3 cc sterile saline -inject into site using original needle if possible 2. Warm pack apply to site without pressure after above injection -etoposide (VP-16), teniposide (VM-26) 1. treat for large volume extravasations 2. 150 units hyaluronidase reconstituted in 1-3 cc sterile saline -inject into site using original needle if possible 3. Warm pack apply to site without pressure after above injection...

Gemcitabine

Am J Clin Oncol 1998 21 505-508 Repeat every 28 days Gemcitabine 1000 mg M2 IV days 1,8,15 REF Crino et al. J Clin Oncol 1999 17 2081-2085 PREMEDICATIONS 1. Compazine 10 mg PO IV 30 minutes before chemotherapy Repeat every 28 days Topotecan Topotecan 1.5 mg M2 d IV (over 30 min) days 1-5 REF Perez-Soler et al. J Clin Oncol 1996 14 503-13 PREMEDICATIONS 1. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy on days 1-5 2. Dexamethasone 20 mg IV 30 minutes...

Head and Neck

Cisplatin methotrexate bleomycin vincristine Methotrexate 40 mg M2 IV days 1,15 Bleomycin 10 units IV days 1,8,15 Vincristine 2 mg IV days 1,8,15 -after 3 courses, methotrexate is given as weekly maintenance -vincristine is discontinued after 6 doses REF Clavel et al. Cancer 1987 60 1173-1177 1. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy on day 4 2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on day 4 3. Compazine 10 mg PO IV 30 minutes before chemotherapy on...

Mesna

Eur J Cancer 1990 26 558-561 -there are multiple variations of this regimen 1. Kytril 1 mg PO IV 30 minutes before chemotherapy and Q12H for 3 additional doses 2. Dexamethasone 20 mg IV on days 1 and 2 Doxorubicin monitor cumulative dose for cardiac toxicity (not to exceed 550 mg M2 or 450 mg M2 with prior chest radiotherapy) vesicant avoid extravasation use 50 for bilirubin 1.5-3.0 use 25 for bilirubin > 3.0 Ifosfamide adequate hydration is necessary to prevent...

Testicular Cancer

Bleomycin etoposide (VP-16) cisplatin REF Einhorn et al. J Clin Oncol 1989 7 387-391 1. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy on days 1-5 2. Dexamethasone 10 mg IV 30 minutes before chemotherapy on days 1-5 1. Give cisplatin delayed-emesis prophylaxis Cisplatin vigorous hydration is required can be nephrotoxic and ototoxic can cause peripheral neuropathy hold or reduce for creatinine > 1.5 Bleomycin give test dose of 1-2 units because of possible acute pulmonary,...

Cisplatin vinblastine

AUC 6 IV (over 1 h) day 1 REF Kelly et al. Proc Amer Soc Clin Onc 1999 abstract 1777 OR AUC 7 IV (over 1 h) day 1 REF Kosmidis et al. Ann Oncol 1997 8 697-699 1. Dexamethasone 20 mg IV 30 minutes before chemotherapy Dexamethasone 20 mg PO 6 and 12 hours prior 2. Diphenhydramine 50 mg IV 30 minutes before chemotherapy 3. Cimetidine 300 mg IV 30 minutes before chemotherapy 4. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy 1. Give cisplatin delayed-emesis prophylaxis 2....

Dosage

Cancer 1986 58 2198-2202 1. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy on days 1-3 2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on days 1-3 OTHER MEDICATIONS 1. Give cisplatin delayed-emesis prophylaxis Cisplatin vigorous hydration is required can be nephrotoxic and ototoxic can cause peripheral neuropathy hold or reduce for creatinine > 1.5 -dose reduced to 75 mg M2 in poor risk patients Mitotane 1000 mg PO REF Bukowski et al. J Clin...

Relapsedrefractory Disease

High-dose cytarabine (ara-c) mitoxantrone High-dose cytarabine (ara-c) fludarabine REF Hiddemann et al. Blood 1987 69 744-749 1. Kytril 1 mg PO IV 30 minutes before and Q12 hours during chemotherapy on days 1-5 2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on days 1-4 3. Dexamethasone eye drops 2 drops each eye Q3H during and for 48-72 hours after completion of cytarabine Ara-C high doses can cause CNS toxicity (cerebellar dysfunction) neurotoxicity increases as infusion time...

Dose administration malaise myalgias fatigueDLT for lowdose administration

-bone marrow suppression -nausea and vomiting -mucocutaneous effects stomatitis, mucositis -cardiovascular effects arrhythmias, hypotension -anorexia -mental status changes confusion, lethargy, psychosis -renal impairment Altretamine -alkylating agent hexamethyl- -nausea and vomiting melamine -bone marrow suppression -diarrhea, abdominal cramps -mucocutaneous effects stomatitis, mucositis -neuropathies -mental status changes -cytoprotectant free radical scavenger -nausea and vomiting...

Irinotecan cisplatin

Dexamethasone 4 mg PO BID for 6 doses after paclitaxel for myalgias 2. Give cisplatin delayed emesis prophylaxis REF Gisselbrecht et al. Cancer 1983 52 974-977 1. Kytril 1 mg PO IV 30 minutes before and 12 hours after chemotherapy on day 1 2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on day 1 1. Give cisplatin delayed-emesis prophylaxis Doxorubicin monitor cumulative dose for cardiac toxicity not to exceed 550 mg M2 or 450 mg M2 with prior chest Radiotherapy vesicant - avoid...

Hematologic Malignancies

Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Vincristine 2 mg IV days 1,8,15,22 Daunorubicin 25 mg M2 IV days 1,8,15,22 Prednisone 60 mg M2 PO days 1-28 L-asparaginase 5,000 units M2 IV days 1-14 Cyclophosphamide 650 mg M2 IV days 29,43,57 -maximum dose 1000 mg 6-Mercaptopurine 60 mg M2 PO days 29-57 Methotrexate 10 mg M2 IT days 31,38,45,52 -maximum dose is 15 mg Cranial 1800-2400 cGy given with phase II radiotherapy induction CONSOLIDATION PHASE I-begins week 20 Vincristine 2 mg...

Chemotherapy Regimens and Cancer Care

VADEMECUM Chemotherapy Regimens and Cancer Care LANDES BIOSCIENCE Georgetown, Texas U.S.A. Copyright 2001 Landes Bioscience All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Please address all inquiries to the Publisher Landes Bioscience, 810 S. Church Street, Georgetown, Texas, U.S.A....