Cisplatin vinblastine

Chemo Secrets From a Breast Cancer Survivor

Breast Cancer Survivors

Get Instant Access

Paclitaxel -followed by Carboplatin

Paclitaxel

-followed by Carboplatin

AUC 6 IV (over 1 h) day 1 REF: Kelly et al. Proc Amer Soc Clin Onc 1999; abstract 1777 OR

AUC 7 IV (over 1 h) day 1 REF: Kosmidis et al. Ann Oncol 1997; 8:697-699

PREMEDICATIONS

1. Dexamethasone 20 mg IV 30 minutes before chemotherapy

Dexamethasone 20 mg PO 6 and 12 hours prior

2. Diphenhydramine 50 mg IV 30 minutes before chemotherapy

3. Cimetidine 300 mg IV 30 minutes before chemotherapy

4. Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy

OTHER MEDICATIONS

1. Give cisplatin delayed-emesis prophylaxis

2. Dexamethasone 4 mg PO BID for 6 doses after chemotherapy (for myalgias)

Repeat every 21 days

-followed by XRT

Vinblastine

Cisplatin

5 mg/M2 100 mg/M2

IV IV

days 1,8,15,22,29 days 1,29

-radiotherapy is started on day 50, to 60 Gy over a 6 week period REF: Dillman et al. NEJM 1990; 323:940-945 PREMEDICATIONS

1. Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy on days 1 and 29

2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on days 1 and 29

3. Compazine 10 mg PO/IV 30 minutes before chemotherapy on days 8, 15, and 22

l JU

su n

Docetaxel/ cisplatin

cisplatin/ etoposide

OTHER MEDICATIONS

1. Give cisplatin delayed-emesis prophylaxis

Cisplatin—vigorous hydration is required; can be nephrotoxic and ototoxic; can cause peripheral neuropathy; hold or reduce for creatinine > 1.5

Vinblastine—use 50% of dose for bilirubin > 3.0; vesicant-avoid extravasation

Docetaxel cisplatin

75 mg/M2 75 mg/M2

IV IV

day 1 day 1

REF: Schiller et al. Proc ASCO 2000:abstract 2 PREMEDICATIONS

Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy on day 1

Dexamethasone 20 mg IV 30 minutes before chemotherapy on day 1

Cemitidine 300 mg IV 30 minutes before chemotherapy Diphenhydramine 25-50 mg IV 30 minutes before chemotherapy

OTHER MEDICATIONS

1. Give cisplatin delayed-emesis prophylaxis

2. Dexamethasone 8 mg PO BID for 8 doses—start day prior to chemo (decreases lower extremity edema)

Repeat every 21 days

Cisplatin—vigorous hydration is required; can be nephrotoxic and ototoxic; can cause peripheral neuropathy; hold or reduce for creatinine > 1.5

Etoposide Cisplatin

100 mg/M2 100 mg/M2

IV IV

days 1-3 day 1

REF: Cardenal et al. J Clin Oncol 1999; 17:12-18

-there are multiple variants of this regimen

PREMEDICATIONS

1. Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy on day 1

2. Dexamethasone 20 mg IV 30 minutes before chemotherapy on day 1

3. Compazine 10 mg PO/IV 30 minutes before chemotherapy on days 2 and 3

OTHER MEDICATIONS

1. Give cisplatin delayed-emesis prophylaxis

Repeat every 21-28 days

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment