Dexamethasone

Vincristine

Doxorubicin

Dexamethasone

REF: Barlogie et al. NEJM 1984; 310:1353-1356

r i

Agent

Dosage

n r

1. Kytril 1 mg POIV 30 minutes before and Q12H during chemotherapy on days 1-4

Breast Cance

Doxorubicin—monitor cumulative dose for cardiac toxicity (not to exceed 550 mg/M2); vesicant—avoid extravasation; use 50% for bilirubin 1.5-3.0; use 25% for bilirubin > 3.0

Dexamethasone

Dexamethasone 40 mg PO days 1-4,9-12,

17-20

f

n

m 3

i 3'

REF: Alexanian: Ann Intern Med 1986; 105:8-11

3

BJ

Repeat every 35 days

Pamidronate (Aredia)

Pamidronate 90 mg IV day 1 REF: Berenson et al. J Clin Oncol 1998; 16:593-602

n

c r

r

Repeat every 28 days

tD

Thalidomide

Thalidomide 200 mg PO QHS daily

n aj

n

aj t

-dose advanced 200 mg every 2 weeks as tolerated

i t'

REF: Desikan et al. Blood 1999; 94(Suppl 1):abstract 2685

t l

Thalidomide—providers and pharmacies must be registered with the S.T.E.P.S program; can cause significant somnolence

O

3

tu i o

Waldenstrom's

Macroglobulinemia

n r

r

Initial therapy frequently consists of an alkylating agent in conjunction with corticosteroids; these regimens can be found

D

in the CLL (chlorambucil, cyclophosphamide) and multiple myeloma (melphalan) sections.

n r

1

Cladribine (2-CdA)

2-CdA 0.1 mg/kg/d CIV days 1-7 REF: Dimopoulos et al. J Clin Oncol 1994; 12:2694-2698

a

Repeat every 28 days for 2 cycles

n aj

a

Fludarabine

Fludarabine 25 mg/M2 IV days 1-5

n r

Z

REF: Foran et al. J Clin Oncol 1999; 17:546-553

7T

Repeat every 28 days to maximal response plus 2 cycles Consider prophylaxis with trimethoprim-sulfanethoxazole

Hematologic Malignancies

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