Preventive Effect Of Shosaikoto On Free Radical Generation During Endotoxemia

The liver is one of the main target organs of endotoxin attack. Detoxification of endotoxin is considered to be mediated mainly by the RES, particularly Kupffer cells, in the liver (Cook et al., 1980 Sakaguchi et al., 1982). Ischemia causes functional and structural damage to tissues or organs by generation of active oxygen species. The modification induced in the apolar side residues of the membrane phosphoglycerides by active oxygen generation are considered to bring about structural...

Contents

13.2 Representative 13.2.1 Xiao-Chaihu-Tang (Sho-Saiko-To in Japanese) (Minor Decoction of 13.2.1.1 Liver, Gallbladder, and Digestive 13.2.1.2 Infection and Inflammatory 13.2.1.3 Fever 13.2.1.4 Allergic Skin-Deep 13.2.1.5 Pernicious 13.2.1.6 Primary 13.2.2 Da-Chaihu-Tang (Dai-Saiko-To, Major Decoction of 13.2.2.2 Cholelithiasis, Biliary Colic, and Infection of the Biliary Tract 183 13.2.2.3 Acute Pancreatitis 13.2.2.4 Higher 13.2.3 Chaihu-Guizhi-Tang (Saiko-Keishi-To, Decoction of Bupleurum and...

Introduction

Chinese herbal medicines have now attracted the attention of practitioners of Western medicine, and are being manufactured in uniform quality and in sufficient quantities for utilization as hospital drugs in Japan. Among these herbal medicines, Xiao-Chaihu-Tang (Sho-saiko-to), which has been used in the treatment of pyretic diseases in China, is an officially approved prescription drug in Japan. As the most commonly administered herbal medicine, Sho-saiko-to is used for the treatment of...

A

3-Acetoxy. 16a-hydroxy-13,28-epoxyolean-11-en-3 p-yl- p-D-glucopyranosyl (1-2) - p-D-glucopyranosyl (1-3) -p-D-fucopyranoside, 76 23-Acetoxy. 16a-hydroxy-13,28-epoxyolean-11-en-3 p-yl- p-D-glucopyranosyl (1-2) - p-D-glucopyranosyl (1-3) -p-D-fucopyranoside, 75 Acetylbupleurotoxin, 147 2-0-Acetylsaikosaponin a, 74 3PP-0-Acetylsaikosaponin a, 74 4-0-Acetylsaikosaponin a, 74 6-0-Acetylsaikosaponin a, 74 23-O-Acetylsaikosaponin a, 74 2-0-Acetylsaikosaponin b2, 76 2-0-Acetylsaikosaponin b3, 78...

H S C

Space of disse I Collagen fibril FIGURE 14.2 Schema of the sinusoidal wall of the liver. Mononuclear cells including Kupffer cells rest on fenestrated endothelial cells. Hepatic stellate cells (HSCs) contact both endothelial cells and hepatocytes. Collagen fibrils course through the space of Disse. HSCs are the main storage sites for retinoids. chronic hepatitis C eventually develops, which can lead to cirrhosis. However, the mechanisms by which HCV induces liver injury and hepatocyte death...

B

Bacterial endotoxin lipopolysaccharide, 160 Bamboo-leaf Chaihu commercial samples of, 10 medicinal uses of, 22 Bencao Tu-jing, 1 Betulin, 123 Betulinic acid, 123 Biliary colic, 183 Biliary tract infection, 183 Black Chaihu, 10 Blood pressure, 140-141 Buddlejasaponin IV, 75, 107-108 Bupleuri radix description of, 35, 123 Japanese source plants of, 41-42 Korean source plants of, 41-42 low-molecular-weight component, 169-170 medicinal uses of, 123 mitogenic substances of description of, 160...

Table 103

Antipyretic Effect of Aqueous Decoction from Chaihu on Typhoid Paratyphoid A and B Triple Vaccine (X S) (n 10) 40.54 0.41 39.78 0.31** 40.30 0.39 40.68 0.54 39.51 0.38 40.18 0.30* 40.76 0.39 39.53 0.29** 40.04 0.36** 40.68 0.32 39.60 0.41** 39.81 0.41** 40.47 0.62 39.38 0.33** 39.63 0.33** 39.92 0.45 39.31 0.39 39.42 0.22 Note Compared with control group *p < 0.05 **p < 0.01. Control group rabbits were administrated an equivalent amount of distilled water. The antipyretic effects of Aqueous...

Scientific Evaluation and Clinical Applications

The prominence of the Bupleurum species cannot be overstated. Across China and Japan, it serves as a main or supplementary ingredient in over two thirds of traditional medications. For over 2000 years, it has been used to treat fevers, intestinal maladies, malaria, and countless other afflictions. Modern research indicates that it may possess anti-tumor qualities, and researchers continue to report its impact on a wide range of ailments, from hepatitis and epilepsy, to irregularity and...

References

Beijing An'ding Hospital. (1982) The Study Group of Integrated Traditional and Western Medicine a clinical analysis of effects on 150 cases of schizophrenia treated by combining Chinese-Western medical means, Chin. J. Modern Dev. Trad. Med., 2(3), 170-171. Cai, J.W. (1986) Da-Chaihu-Tang treatment of acute pancreatitis-experiences of 132 cases, Liaoning J. Trad. Chin. Med., 10(2), 21. Chen, L.B. (1997) 27 cases of male infertility treated by Longdan-Xiegan-Tang, J. Anhui TCM Coll., 116(6), 28....

Info

International Standard Book Number-10 0-8493-9265-9 (Hardcover) International Standard Book Number-13 978-0-8493-9265-8 (Hardcover) Library of Congress Card Number 2005035151 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume...

C

Calcium channel blocker, 216 p-Caryophyllene, 111 Central nervous system, 137 C-glycoside 65, 104 Chaihu anodynic effect of, 137-138 antibacterial properties of, 139-140 anticancer effects, 146 anti-inflammatory activity of, 136 antimutagenesis effects, 146 antioxidation effects, 146 antipyretic effect of, 137 antiviral properties of, 139-140 blood pressure reductions using, 140-141 central nervous system effects, 137 commercial samples of, 10 description of, 135 enzyme activity affected by,...

Oh

FIGURE 9.6 Avicularin and guaijaverin from B. falcatum subsp. cernum. structures were established on the basis of their spectroscopic data in comparison with authentic compounds and references from the literature (data not yet published). These compounds were in good agreement with those reported by Hegnauer (1990) (Figure 9.6). Bupleurum flavum Forskal, an annual species typical of the eastern regions of Mediterranean area (Bulgaria, Greece, and Turkey), was also investigated in our...

R

Reactive oxygen species, 206 Rectal prolapse, 190 Rectangular pleurotreme pollen grain, 31 Red Chaihu commercial samples of, 10 medicinal uses of, 22 Reflex esophagitis, 182 Respiratory control index, 219 Reticuloendothelial system, 213-214 Rhomboidal goniotreme pollen grain, 27 Roots, See also Chaihu annual requirement of, 1 description of, 23 essential oils of, 2 illustration of, 24-25 oil cavities of, 23 saikosaponins in, 59 Rotundioside A, 79 Rotundioside B, 80 Rotundioside C, 80...

E

Endotoxin-induced nitric oxide, 219-221 Chaihu-Guizhi-Tang for, 184 Saiko-Ka-Ryukotsu-Borei-To for, 189 Si-Ni-San for, 187 Xiao-Chaihu-Tang for, 183 Epstein-Barr virus, 146 Essential oils anti-inflammatory activity of, 3, 126-127 of Bupleurum fruticosum L., 111-112, 126-127 from Spanish Bupleurum spp., 106-107 Exocarp, 26-27

Cn1395947 Cn1389213

Medicine composition for treating mammary gland Zhang Huifang (CN) proliferation, and its preparation method Medicine composition for treating biliary calculus, and its preparation method Medicine for treating throat disease and its preparation method Medicine compositions for treating hepatitis, and its preparation method New use of powder for regulating liver and spleen and its active part Lireqing injecta (for clearing heat and diminishing inflammation) Preparatory Chinese medicine for...

Treatment Of Acyesis

CN1253830 Chinese medicine prescription for curing hepatitis, cholangitis, pancreatitis, and cirrhosis CN1259380 Medicine for giving up drugs CN1257725 Chinese medicine for treating bone fracture CA2389993 Herbal compositions for treating gastrointestinal disorders CN1294002 Chinese medicine for treating neuropathy CN1253808 Chinese medicine abortifacient CN1289611 Quick-acting Chinese medicine for treating cirrhosis and its preparation process CN1248469 Powder medicine for treating hepatitis B...

Patents Containing Bupleurum

CN1593636 Orally disintegrating tablet of Bupleurum root and its preparation CN1583158 Medicinal composition for wind-cold pathogen by exopathogen and its preparation CN1586602 Medicinal composition for treating cholelithiasis and its preparation method CN1586573 Pill for reducing transaminase and liver protection CN1586572 Oral liquid for female sterility CN1586541 External use medicine for preventing respiratory infectious disease and its preparation method CN1586522 Chinese medicine capsule...

Representative Prescriptions

Because several effects of Bupleurum root are very significant, and the clinical application is also very effective, its use with other drugs has become very important. Many prescriptions include Bupleurum root whether or not it acts as the principal drug. These prescriptions are widely used today and are very effective there are even some new applications. This chapter introduces several representative prescriptions and their major clinical applications. 13.2.1 Xiao-Chaihu-Tang (Sho-Saiko-To...

Table 131

Other Useful Preparations Containing Bupleurum Used in Traditional Chinese Medicine Xuefu-Zhuyu-Tang (Decoction for Removing Blood Stasis in the Chest) Chai-Ling-Tang (Sairein-To) (Decoction of Bupleurum and Poria) Chaiping-Tang (Decoction of Bupleurum for Stomach) Chaihu-Guizhi-Ganjiang-Tang (Saiko-Keishi-Kankyo-To) (Decoction of Bupleurum, Cinnamon Twig and Dried Zingiberis ) Some Correction of Chinese Traditional Medicine ZhuDanxi's Thoughtway and Methods in Traditional Chinese Medicine Some...

Cn1090193 Cn1078902 Ep0568001

Oral liquid for curing hepatitis B, and its production Yuehan Guo (CN) Drug for external use for treating necrosis of femoral head Drug for external use for treating necrosis of femoral head Anti-cold inhalation and its preparation method Healthful oral liquid for liver Xugan oral liquor made of a plant material for curing deficiency cold Natural medicine napkins for treating dysmenorrhea Medicine for curing tuberculosis Powder for curing wind-cold type of common cold and its preparation method...

Main Chemical Constituents Of Italian Bupleurum

A relatively small number of Bupleurum species about a quarter of the total have been subjected to phytochemical investigations the main constituents and the most bioactive components are triterpene glycosides of the oleanane series named saikosaponins Nose et al., 1989 Guinea et al., 1994 , but occurrence of polyphenolic compounds, i.e., phenylpropanoids Massanet et al., 1997 , lignanes Luo et al., 1993 Estevez-Braun et al., 1994b, 1995 , coumarins Gonzalez et al., 1975 Pistelli et al., 1996 ,...

Shengli Medicine

Bupleurum is a genus of family Umbelliferae Apiaceae , comprising about 200 species and primarily located in the Northern Hemisphere, Eurasia, and North Africa. The anatomy of the more important species and their geographical distribution are given in Chapters 2 and 3. The chromosomes are considered in relation to classification and cross-breeding in Chapter 4. Under the name of Chaihu Saiko in Japanese and Shiho in Korean , the roots of several species from the genus have been frequently used...