Recent new and exciting findings for the genome-wide analysis of the target loci of H3K27 methylation in the embryonic stem cells and other cell types are timely (Lee et al., 2006; Boyer et al., 2006; Bernstein et al., 2006; Bracken et al., 2006,). Not only H3K27 methylation, but other histone methyl-lysine codes including H3K9 methylation are coordinately integrated into the histone code network and regulate various kinds of biological reactions including transcriptional regulation, cell growth, differentiation/pluripotency and DNA repair. In this context, our further studies and understanding of the dynamics and regulation of histone lysine methy-lation would be crucial for our health and the cure diseases.

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