Radiotherapy, administred as either P32 (86), as total body irradiation (87), extracorporal irradiation of blood (88), or thymic irradiation (89), was found to be effective in a few patients, but severe myelosuppression is a frequent sequel to this treatment. Splenic irradiation has been used more often, mainly in patients with massive splenomegaly, when splenectomy was difficult and the patient had associated autoimmune cytopenias. Recently, the UK MRC observed a better survival for patients treated bywith splenic irradiation as compared with CLB or CLB + PRD, in two randomized trials, but this difference was not significant (12). Finally, irradiation of large lymph nodes may be used in patients who are resistant to chemotherapy.

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