Because of the many deficiencies in host defense mechanisms caused by the disease process or its therapy, it is not surprising that a wide variety of pathogens have been reported in CLL. Often it is difficult to identify the specific underlying deficiency responsible for susceptibility to a particular infection. Reports of association based on a single case or only a few cases may be misleading. Obviously, in order to contract an infection, the patient must be exposed to the pathogen, and some pathogens truly associated with CLL can be contracted only in limited geographical regions. Despite these caveats, it is clear that some infections are associated with CLL.
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