Vh Mutation Cd38 And Genomic Aberrations In Bcll

Several studies over the past few years have demonstrated that there is somatic hypermutation of the rearranged VH genes (mutated VH) in about half of the B-CLL cases (123-125). This was surprising since B-CLL had been considered a pregerminal center-derived lymphoma. Pivotal studies on a small number of patients showed an unfavorable prognosis in B-CLL with unmutated VH genes (7,8). In some studies, there was a strong correlation between CD38 expression of the B-CLL cells and the VH mutation status (7,128). Other authors could not confirm this, so it still remains unclear whether CD38 expression can be applied as a prognostic surrogate marker for the VH mutation status (129-131).

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