Several studies over the past few years have demonstrated that there is somatic hypermutation of the rearranged VH genes (mutated VH) in about half of the B-CLL cases (123-125). This was surprising since B-CLL had been considered a pregerminal center-derived lymphoma. Pivotal studies on a small number of patients showed an unfavorable prognosis in B-CLL with unmutated VH genes (7,8). In some studies, there was a strong correlation between CD38 expression of the B-CLL cells and the VH mutation status (7,128). Other authors could not confirm this, so it still remains unclear whether CD38 expression can be applied as a prognostic surrogate marker for the VH mutation status (129-131).
Was this article helpful?