Alternative Cure for Eczema
Dermatitis herpetiformis was described 100 years ago by Louis Duhring as a relatively rare skin disease characterized by a rash with small blisters and intense itch. Predilection sites are on the elbows, knees and buttocks, but lesions can also be found on the scalp, axillary folds and back. The onset in young adults is usually sudden. Diagnosis is based on biopsy from the uninvolved skin immunofluorescence shows characteristic granular IgA deposits along the basement membrane. In dermatitis herpetiformis lesions, subepidermal blisters with cellular inflammatory infiltration are found. The rash is gluten-dependent and the improvement in skin lesions occurs slowly even on a strict gluten-free diet it lasts several months before the patient can stop using dapsone (diaminodiphenyl sulphane) which controls the rash in few days and, therefore, it has been used for years in the treatment of dermatitis herpetiformis 30, 31 . Even though less than 10 of patients with dermatitis herpetiformis...
Many medical conditions associated with chronic stimulation of the immune system, such as repeated infections, allergic conditions, or autoimmune disease, have been reported to increase the risk of MM. In a case-control study, past history was abstracted from medical records for leukemia, n 299 non-Hodgkin's lymphoma (NHL), n 100 and MM, n 175 patients, and matched with 787 controls. Prior histories of eczema and musculoskeletal conditions were associated with higher risk for MM with no role identified for chronic antigenic stimulation in the etiology of leukemia or NHL.32 Another case-control study of 100 MM cases in whites showed no associations between MM and history of medical conditions that cause prolonged stimulation of the immune system, like
Eczema is a dermatitis that usually begins as patchy redness. If untreated, small breaks develop in the skin patches and can progress to scaling, thickening, and cracking. It most often occurs on the hands, but can appear anywhere on the skin. Although there are many triggers of eczema, one of the most common causes is food sensitivity. Eczema can also be caused by exposure to environmental agents such as chemicals, soaps, and detergents. Metal compounds in earrings, watches, or other jewelry (particularly metal alloys containing nickel) can trigger eczema.
A careful elimination diet (see pp.205) can identify food sensitivities that trigger eczema.17 The most common offending foods are milk, eggs, fish, cheese, nuts, and food additives. Cold-pressed nut and seed oils are high in beneficial EFAs important for skin health and should be consumed regularly. Disturbances in fatty acid metabolism in the skin can produce or aggravate eczema impaired production of omega-3 fatty acids and GLA can increase inflammation in the skin (see pp.89).18
The skin exerts a number of essential protective functions ensuring homeostasis of the whole body. In the present review barrier function of the skin, thermoregulation, antimicrobial defence and the skin-associated immune system are discussed. Barrier function is provided by the dynamic stratum corneum structure composed of lipids and corneocytes. The stratum corneum is a conditio sine qua non for terrestrial life. Impairment of barrier function can be due to injury and inflammatory skin diseases. Textiles, in particular clothing, interact with skin functions in a dynamic pattern. Mechanical properties like roughness of fabric surface are responsible for non-specific skin reactions like wool intolerance or keratosis follicu-laris. Thermoregulation, which is mediated by local blood flow and evaporation of sweat, is an important subject for textile-skin interactions. There are age-, gender- and activity-related differences in thermoregulation of skin that should be considered for the...
P. cm. - (Current problems in dermatology v. 33) Includes bibliographical references and index. ISBN 3-8055-8121-1 (hard cover alk. paper) 1. Contact dermatitis. 2. Textile fabrics-Physiological aspects. 3. Biomedical materials. I. Hipler, U.-C. (Uta-Christina) II. Elsner, Peter, 1955- III. Series.
Recently, reports linking Chinese herb remedies to fatal renal failure have appeared 78, 79 . The remedies have been taken for weight loss or the treatment of eczema. The offending compound is thought to be aris-tolochic acid which is the acknowledged nephrotoxin that was identified as contributing to the progressive interstitial nephritis that lead to renal failure and death in the Belgian experience 78 . In a recent editorial, De Broe 79 speculates that combining a potentially neph-rotoxic agent, such a Chinese herbs with a renal vaso-constrictive agent, may account for the observation that not all patients who use the herbal product develop ARF. In the UK it is estimated that over 3000 clinics were prescribing Chinese herbs in 1999 80 .
Seborrheic dermatoses and other forms of scaly skin rash may respond to biotin, particularly when taken as part of a complete vitamin B complex in conjunction with essential fatty acids (omega-6 and omega-3 fatty acids). 1 These dermato-logic disorders may be due to impairments of essential fatty acid metabolism in the skin, produced by abnormal biotin metabolism or deficiency.
Contact dermatitis and periocular edema can also result. Other more severe effects, such as pulmonary edema, have been documented when concentrations are several hundred-fold above what produces intolerable symptoms or with trauma associated with the explosive device used to deliver the chemical agent (6,15).
Angioimmunoblastic T-cell lymphoma is a relatively rare disorder with distinctive clinical behavior and generally poor outcome. This entity is part of a spectrum of clinical conditions ranging from angioim-munoblastic lymphadenopathy with dysproteineimia (AILD) to malignant lymphoma. Patients with AILD are at risk of developing malignant lymphomas that may be of either T-cell or B-cell lineage, while clonal populations of T cells may also be seen in AILD cases without overt histologic evidence of malignant lymphoma. Furthermore, investigators have reported cases of de novo lymphomas that have histologic features similar to those of lymphomas arising from an AILD background. Patients with angioimmunoblastic T-cell lymphoma often exhibit systemic disease with generalized lymphadenopathy, fever, weight loss, malaise, and skin rash. They tend to be older males with nodal and extranodal disease and numerous adverse risk factors. Laboratory studies reveal anemia (often positive for direct...
A, B, C, flustraminol A, B and dihydroflustramine C, which inhibits cell division of the fertilized sea urchin eggs. The bryozoan Phidolopora pacifica has yielded phidolopin, a purine derivative largely responsible for high order of antifungal and antialgal activities.198,199 Several macrolides like bryostatin-1 and bryostatin-2 were isolated from Bugula neritina.200'202 Some of these metabolites show high order of antineoplastic activity. 2-Hydroxyethyl dimethyl sulfoxonium ion acts as an allergen. These compounds are isolated from marine bryozoan Alcyonidium gelatinosum.203 The bryozoan causes an eczematous allergic contact dermatitis called 'Dogger bank itch'.
Ample intake of the EFAs (see pp.89) is vital during infancy. Because infants absorb fat poorly and have low fat stores, they are particularly sensitive to EFA deficiency and quickly develop signs of deficiency if fat intake is low. Infants fed formulas deficient in li-noleic acid for just a few days may develop a dry, eczema-like, flaky skin rash, diarrhea, hair loss, and impaired wound healing. Deficiency also impairs platelet function and lowers resistance to infection. Regular intake of EFAs is therefore critical during infancy, and although breast milk is rich in EFAs, not all infant formulas have adequate amounts.
And dependence and their danger in overdose. Chloral hydrate (3) (see Table 5.5) seems the least problematic with relatively low abuse potential it is still used as an alternative to benzodiazepines. The adverse effects include gastric irritation, light headedness, ataxia, nightmares, excitement, confusion, allergic reactions, and skin rash. It also causes drowsiness and motor incoordination therefore, chloral hydrate should not be used concomi-tantly with other CNS depressant drugs such as alcohol. The adverse effects of ethchlorvynol (4) (see Table 5.5) are similar to those of
Particularly important is gamma-linoleic acid (GLA), a fatty acid that can be synthesized in small amounts from dietary linoleic acid. GLA is also found in high amounts in a few plant oils, including borage oil and evening primrose oil. Without adequate GLA and its products, skin will dry out, wrinkle, and age prematurely. Because the skin cannot easily synthesize adequate GLA during times of increased need - exposure to cold, dry air, allergens, aging, eczema, stress - supplementation with evening primrose oil rich in GLA can be beneficial.3 To protect and maintain the natural skin oils, ample vitamin E and beta-carotene are essential. (For a more detailed discussion of these important polyunsaturated fats, including GLA, see pp.89).
The formation of tight complexes of the peptidomacrolides FK506 (also known as tacrolimus) and rapamycin (also known as sirolimus) with endogenous FKBP12 inhibits T cell proliferation via different pathways. Similar to CsA in the Cyp18 CsA complex, FK506 when bound to FKBP12 experiences gain of function that leads to calcineurin inhibition. The FKBP12 FK506 complex inhibits calci-neurin more powerful when compared to Cyp18 CsA. Dissociation constants for ternary calcineurin FKBP FK506 complexes containing different FKBP range from 88 nmol L-1 to 27 imol L-1 87 . Recently it was found that FKBP12 is the only FKBP family member to play a key role in FK506-mediated immunosuppression 88 . A topically active FK506 derivative (pimecrolimus) with reduced system exposure and thus increased immunological safety has been launched for therapeutic application in atopic dermatitis, psoriasis, and allergic contact dermatitis 89 .
Coeliac patients have a higher incidence of non-Hodgkin's lymphoma than that of the general population 7, 34-39 , Malignancy develops in 8-13 of patients. EATL is slightly more frequent in males and has its peak in the sixth decade of life. An interesting recent finding shows that the incidence of lymphoma in CD diagnosed in elderly patients (over 60 years) was much higher (23 ) than that in younger population (8 ). Moreover, other autoimmune diseases, dermatitis herpetiformis and autoimmune thyroiditis, were common in this group of patients 10 . The relationship between EATL and CD is underlined by the finding of the CD associated DQA1 0501, DQB1 0201 phenotype in EATL patients.
In the early 1960s, Bauer et al. first showed that methisazone protected infant mice from fatal encephalitis caused by intracerebral injection of variola virus (464). Around that time methisazone was used in a case of eczema vaccinatum and this appeared to be the first clinical use of antiviral drug in man (464). As discussed above, clinical experience with methisazone has also included the treatment of vaccinia gangrenosa, prophylaxis of vaccinia infection, prophylaxis of smallpox (the main indication for the use of the drug), and treatment of smallpox (466). In any event, methisazone could serve as the lead for the design of a next generation drug with much improved pharmacological properties and safety profile.
The formulations are described in order of decreasing water content. All water-based formulations must contain preservatives, e.g. chlorocresol, but these rarely cause allergic contact dermatitis. Water is the most important component. Wet dressings are generally used to cleanse, cool and relieve pruritus in acutely inflamed lesions, especially where there is much exudation, e.g. atopic eczema. The frequent reapplication and the cooling effect of evaporation of the water reduce the inflammatory response by inducing superficial vasoconstriction. Sodium chloride solution 0.9 , or solutions of astringent2 substances, e.g. aluminium acetate lotion, or potassium permanganate soaks or compresses of approx. 0.05 , can be used. The use of lotions or Nonemulsifying ointments do not mix with water. They adhere to the skin to prevent evaporation and heat loss, i.e. they can be considered a form of occlusive dressing (with increased systemic absorption of active ingredients) skin maceration may...
Participants in both the DVA Persian Gulf Health Registry and the CCEP registry represent a broad cross-section of service members who deployed to the Gulf, although the demographics of participants as a group differ from the deployed population in some respects as discussed above. At the time the comprehensive reports were published, 18,075 individuals had participated in CCEP, and 52,216 individuals had been evaluated through the PGHR.56-60 The Presidential Advisory Committee (PAC) combined the data from both sources in their evaluation of the findings of the registries.59 As stated, not all registry participants are ill 10 of CCEP participants are asymptomatic, while 12 of PGHR participants report no symptoms. Symptomatic participants in both registries reported a broad range of symptoms spanning a variety of organ systems. The most common symptoms reported in CCEP participants were joint pain, fatigue, headache, and skin rash. Most commonly reported symptoms for the PGHR were...
The blue-green algae show many structural features in common with bacteria, notably the absence of membrane bound organelles. They are called algae since they contain chlorophyll-a and related compounds. All prokaryotes can convert atmospheric nitrogen into ammonia and therefore, nitrogenous metabolites are frequently formed in the blue-green algae. Some of these metabolites exhibit potent biological activities. For example, a number of strains of Lyngbya majuscula which cause contact dermatitis known as Swimmer's itch', produce toxins, lyngbyatoxin and debromoaplysiatoxin. Hormothamnione (20) is an unusual chromone from Hormothamnion enteromorphoides, the biogenesis of which cannot be explained by the acetate or shikimate pathway.43 No terpene appears to have been isolated from cyanobacteria, although compounds incorporating isoprenoid units, such as lyngbyatoxin A (18)44-46 and hapalindole (21)47-50 have been isolated. P-Cyclocitral (19) isolated from Microcystis species, is a...
Found in warm water have been implicated as the causative agents of Swimmer's'itch, a form of contact dermatitis. Lyngbyatoxin-A ( 1)28-5 was isolated from L. majuscula and the gross structure was determined as the prenylated cyclic dipeptide. The configuration at the C-14 quaternary carbon in (1) was subsequently shown to be (R) by degradation of (1) to dimethyl 2(S)-2-ethyl-2-methylglutarate.36 Lyngbyatoxin-A (1) represents a new structural class of potent tumor promoters that exhibits tumor promoting activity in mice similar to that induced by phorbol esters.37 Lyngbyatoxin-A was also found to kill baitfish (Poecilia vittata) at a concentration of 0.15 g mL in seawater suggesting L. majuscula perhaps produce lyngbyatoxin-A as an ichthyotoxic chemical for defense. Lyngbyatoxin-A has been synthesized.38
Genase, significantly increases the development of symptomatic anemia. The clinically significant adverse events associated with ribavirin treatment include anemia and depression (38,39). In the authors' clinical experience of treating several hundred patients with IFN plus ribavirin for CHC, the most important side effects of ribavirin have been anemia, which has been particularly severe among men treated with high doses (1200 mg d), depression and development of a pruritic, scaling skin rash (Bonkovsky, unpublished observation). These have required dose reduction or cessation of ribavirin therapy in 20 of treated patients (39).
An anti-MDC antibody inhibits eosinophil recruitment to the lungs and protects against methacholine-induced bronchial hyperreactivity (168). Additionally, an anti-TARC antibody has been shown to attenuate an OVA-induced inflammation and airway hyper-responsiveness (169). In contrast to these results obtained from the neutralization of CCR4 ligands, the receptor knockout does not show any phenotype different from that of wild-type mice in the same models of allergic lung inflammation (170). In human tissues, CCR4 is expressed in all IL-4-positive cells in the bronchial mucosa of asthmatic patients that have been challenged 24 h before tissues were collected (171).In the same study, CCR4 ligands were found to be highly expressed by the airway epithelium in the same patient population. It has also been suggested that CCR4 and its ligands are also involved in other inflammatory diseases such as psoriasis and atopic dermatitis (172-174). These last observations correlate with the fact that...
The commonest skin conditions associated with IFN-ribavirin therapy are nonspecific skin rashes, itchiness, or dry, thickened skin, which may resemble either drug eruptions or a nonspecific dermatitis. Skin rash is more common with combination therapy than with ribavirin alone (28 vs 8 ). The rash can appear on any part of the body, and is frequently pruritic. In many cases, the rash is transient, and resolves over time, requiring no alteration of medication. In patients who have a major drug eruption, reduction in the dose of ribavirin, or even stopping ribavirin, may be necessary. In mild cases, a 0.05 steroid cream will improve the skin rash, and benadryl or other antihistamines can be used for the pruritis. Pruritus without skin rash is reported in 29 of patients taking Rebetron, compared to 9 on IFN. The dry skin can be treated by avoiding long baths or powerful soaps, and by using skin-moisturizing creams. Photo-allergic skin rash and sensitivity to UV light can be seen with...
Trimethoprim-sulfamethoxazole (TMP-SMX) has been investigated as a prophylactic agent in a small, randomized, multicenter trial of newly diagnosed patients undergoing chemotherapy for MM.35 This antibiotic was chosen based on low expense, tolerabil-ity, and previous experience in other patients with other causes of immunocompromise.35 Fifty-seven patients with MM were randomized to receive prophylaxis consisting of two TMP-SMX 80 400 mg tablets every 12 hours for 2 months, or to a control group that received no prophylaxis. Chemotherapy was administered to all patients 50 received melphalan plus prednisone, while all others received more intensive combination chemotherapy. The two groups were well balanced with respect to age, gender, and stage of disease. Data collection continued for 3 months after the start of chemotherapy for patients in both groups. Fifty-four patients of the 57 entered were evaluable. Overall, 12 (46 ) of the patients assigned to the control group and five (18 )...
Patients (27 ) with HER2 neu overexpressing tumors. Seventy-nine percent of patients had involvement of the viscera. The majority of individuals (78 ) had received at least two prior cytotoxic treatments and all ErbB2 positive patients (36 ) had been previously treated with trastuzumab. The treatment was well tolerated with the exception of diarrhea. The results, however, noted minimal response. One patient had a partial response and five patients had stable disease lasting at least four months in duration. Median overall survival was 144 days (range 110242 days). Median progression-free survival was 57 days (range 16-205+ days). The authors noted that some patients experienced an improvement in symptoms such as bone pain. Five patients (42 ) experienced palliation of pain. Similar to previous studies, toxicities consisted of grade 3 diarrhea, nausea, vomiting, and a rash. Skin rash occurred in 44 of patients (n 28), four of which had grade 3 rash. Four patients required a dose...
Simple patch skin testing is naturally most useful in diagnosing contact dermatitis, but it is unreliable for other allergies. Skin prick tests are helpful in specialist hands for diagnosing IgE-dependent drug reactions, notably due to penicillin, cephalosporins, muscle relaxants, thiopental, streptokinase, cisplatin, insulin and latex. They can cause anaphylactic shock. False positive results occur.
Irritant or allergic contact dermatitis is eczematous and is often caused by antimicrobials, local anaesthetics, topical antihistamines, and increasingly commonly by topical corticosteroids. It is often due to the vehicle in which the active drug is applied, particularly a cream.
Adverse effects The major adverse effect associated with ibritumomab tiuxetan is myelosuppression, consisting mainly of neutropenia and thrombocytopenia.45 46 Because of this, several parameters must be met before patients can be treated with this agent. Qualifications for therapy include 100,000 cells mm3, and no history of hypocellular marrow or failed stem cell collection.28 The average time to neutrophil nadir is 62 days, while platelets typically nadir around day 53. Cells recover after approximately 22-35 days.43 Additional adverse effects include those seen with other anti-CD20 agents, such as fever, hypotension, chills, skin rash, and rarely nausea and vomiting.45 individuals because of fluctuating clearance rates of the compound.1 The major dose-limiting toxicity of 131I tositumomab is myelosuppression, similar to that seen with 90Y ibritumomab. Therefore, patients must have 100,000 cells mm3, and no history of hypocellular marrow or failed stem-cell collection in order to...
Alopecia, rash, contact dermatitis, urticaria, nausea, vomiting, mucositis, diarrhea, abdominal pain, fever, chills, and (occasionally) anaphylaxis are observable. When given along with cyclophosphamide, its cardiotoxicity is enhanced and enhanced toxicity is seen when given concurrently with methotrexate.
Swelling, redness, and tenderness, although frequently caused by trauma, are not specific signs of injury. Although it is important to record whether these features are present, it must be remembered that there also may be nontraumatic causes for these lesions (e.g., eczema dermatitis or impetigo).
Topical nitrogen mustard has been used for management of MF since 19 5 9.24 Many investigators have demonstrated the efficacy of topical nitrogen mustard in patch and or plaque disease of MF.25 A recent update of 203 patients with MF (clinical stage I-III) treated with topical nitrogen mustard demonstrated CR rates of 76-80 for patients with stage IA and 35-68 for those with stage IB disease.26 Fewer than 10 of patients developed progression of disease. Most common side effects were irritant contact dermatitis. No secondary malignancies related to therapy were reported. Topical Carmustine (BCNU) showed similar results, with an 86 CR rate however, patients may develop progressing teleangiec-tasias from treatment.27 Mild leukopenia occurred in 3.7 of the patients.
The methyl, ethyl, propyl, and butyl esters of p-hydroxybenzoic acid (parabens) are used as preservatives for liquid dosage forms of pharmaceuticals and in cosmetics and industrial products. They are active against bacteria, yeasts and molds. Parabens are effective in low concentrations (0.1-0.3 ) that are devoid of systemic effects, but as constituents of antibacterial ointments they can cause severe contact dermatitis. gal activity, but it is less potent than phenol. Nevertheless, its keratolytic properties make it useful in treating conditions such as acne, ringworm, eczema, and psoriasis. Resorcinol monoacetate is a prodrug that slowly liberates resorcinol. It has weaker but more prolonged
Eczema e.g. penicillins, phenothiazines. Diagnosis. The patient's drug history may give clues. Reactions are commoner during early therapy (days) than after the drug has been given for months. Diagnosis by readministration of the drug (challenge) is safe with fixed eruptions, but not with others, particularly those that may be part of a generalised effect, e.g. vasculitis. Patch and photopatch tests are useful in contact dermatitis, for they reproduce the causative process but should be performed only by those with special experience. Fixed drug eruptions can sometimes be reproduced by patch testing with the drug over the previously affected site.
The first 4 years of childhood (De Bolle et al. 2005). The time of HHV-6A infection is still unknown, but is thought to occur following infection with HHV-6B. As a consequence, roseoloviruses are ubiquitously spread in the general adult population, usually reaching a seroprevalence of greater than 95 . Primary infection with HHV-6b or HHV-7 results in an acute febrile illness that is in some cases followed by the appearance of a mild skin rash on the face and trunk (i.e., exanthem subitum or roseola infantum Yamanishi et al. 1988 Tanaka et al. 1994). Interestingly, infection with HHV-6A is usually asymptomatic (Dewhurst et al. 1993 Stodberg et al. 2002 Freitas et al. 2003). Clinical complications of (primary) HHV-6 and -7 infections include febrile seizure, but also meningoencephalitis, encephalopathy, and multiple sclerosis (for a review see De Bolle et al. 2005). Importantly, primary HHV-7 infection can reactivate HHV-6 (Frenkel and Wyatt 1992 Katsafanas et al. 1996 Tanaka-Taya et...
Superficial bacterial infections, e.g. impetigo, eczema, are commonly staphylococcal or streptococcal. They are treated by a topical antimicrobial for less than 2 weeks and applied twice daily after removal of crusts that prevent access of the drug, e.g. by a povidone-iodine preparation. Very extensive cases need systemic treatment. Combination of antimicrobial with a corticosteroid (to suppress inflammation) can be useful for secondarily infected eczema. Virus infections. Topical antivirals aciclovir (acyclovir). (see p. 257). Aciclovir is used systemically for the potentially severe infections, e.g. eczema herpeticum.
Scratching or rubbing seems to give relief by converting the intolerable persistent itch into a more bearable pain. Firm pressure with a finger may relieve the itch. A vicious cycle can be set up in which itching provokes scratching and scratching leads to skin lesions which itch, as in lichenified eczema. Covering the lesion or enclosing it in a medicated bandage so as to prevent any further scratching or rubbing may help. Topical corticosteroid preparations are used to treat the underlying inflammatory cause of pruritus, e.g. in eczema. can be helpful in localised pruritus, but extensive use induces sedation like other topical antihistamines it induces allergic contact dermatitis. Pruritus ani is managed by attention to hygiene, emollients, e.g. washing with aqueous cream, and a weak corticosteroid with antiseptic anticandida application used as briefly as practicable (some cases are a form of neurodermatitis). Secondary contact sensitivity, e.g. to local anaesthetics, is common.
Antigen-specific receptors develop on T-lympho-cytes. Subsequent administration leads to a local or tissue allergic reaction, e.g. contact dermatitis. Cross-allergy within a group of drugs is usual, e.g. the penicillins. When allergy to a particular drug is established, a substitute should be selected from a chemically different group. Patients with allergic diseases, e.g. eczema, are more likely to develop allergy to drugs.
Curing Eczema Naturally
Do You Suffer From the Itching, Redness and Scaling of Chronic Eczema? If so you are not ALONE! It strikes men and women young and old! It is not just