Phencyclidine, known as "angel dust," is usually smoked, although it can be taken orally, intravenously, or by nasal inhalation. It is commonly used as an additive to other drugs, such as cannabis or LSD, and the symptoms and signs may vary greatly (49). At low doses, euphoria, relaxation, and an altered body image may occur, but at higher doses, there may be agitation, bizarre behavior, and a paranoid psychosis (50). Analgesia occurs, which may lead to self-injury. Physical effects include nystagmus (lateral and vertical), and with severe intoxication there is adrenergic stimulation with hypertension, tachycardia, flushing, hyperthermia, and cholinomimetic stimulation with sweating, hypersalivation, miosis, dystonia, ataxia, and myoclonus eventually resulting in coma, respiratory arrest, and circulatory collapse (51). Death may also result from intoxication or from violent behavior. Chronic effects of phen-cyclidine abuse include memory impairment, personality changes, and depression; however, there is probably no physical dependence.
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