And Michael R Garrett MS mba

Contents

Introduction Results Perspectives References

Changes in blood pressure (BP) from low to high, are genetically controlled by many genes. Identifying genes that regulate BP is important for two major reasons: (1) for delineating the biochemical/physiological mechanisms for BP control; and (2) for utilizing this knowledge to improve clinical management strategies for maintenance of normal physiological BP, which is an important factor in reducing the risk for susceptibility to cardiovascular diseases.

Genetic approaches to identify BP regulatory genes involve the use of rat models with elevated BP (hypertension). Typically, genetic linkage analyses and substitution mapping using congenic strains are performed. These studies are designed to enable the identification of BP regulatory genes primarily by virtue of their location on the rat genome. This chapter captures the current status of studies aimed at identifying BP causative genes using various congenic rat strains.

Key Words: Hypertension; genetic; rat; animal model; QTL; cardiovascular; renal; disease causative genes.

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