1. Luft FC. Hypertension as a complex genetic trait. Semin Nephrol 2002;22:115-126.

2. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001;104:545-556.

3. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation1999;99:1407-1410.

4. Hunt SC, Ellison RC, Atwood LD, Pankow JS, Province MA, Leppert MF. Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension 2002;40:1-6.

5. Kristjansson K, Manolescu A, Kristinsson A, et al. Linkage of essential hypertension to chromosome 18q. Hypertension 2002;39:1044-1049.

6. Rice T, Rankinen T, Chagnon YC, et al. Genomewide linkage scan of resting blood pressure: HERI TAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics. Hypertension 2002;39:1037-1043.

7. Levy D, DeStefano AL, Larson MG, et al. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension 2000;36:477-483.

8. Caulfield M, Munroe P, Pembroke J, et al. Genome-wide mapping of human loci for essential hypertension. Lancet 2003;361:2118-2123.

9. Kageyama R, Ohkubo H, Nakanishi S. Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence. Biochemistry 1984;23:3603-3609.

10. Corvol P, Jeunemaitre X. Molecular genetics of human hypertension: role of angiotensinogen. Endocr Rev 1997;18:662-677.

11. Gould AB, Green D. Kinetics of the human renin and human substrate reaction. Cardiovasc Res 1971;5:86-89.

12. Fasola AF, Martz BL, Helmer OM. Renin activity during supine exercise in normotensives and hypertensives. J Appl Physiol 1966;21:1709-1712.

13. Watt GC, Harrap SB, Foy CJ, et al. Abnormalities of glucocorticoid metabolism and the renin- angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J Hypertens 1992;10:473-482.

14. Campbell DJ, Habener JF. Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest 1986;78:31-39.

15. Tanimoto K, Sugiyama F, Goto Y, et al. Angiotensinogen-deficient mice with hypotension. J Biol Chem 1994;269:31334-31337.

16. Kim HS, Krege JH, Kluckman KD, et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995;92:2735-2739.

17. Krege JH, Kim HS, Moyer JS, et al. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 1997;29:150-157.

18. Gaillard I, Clauser E, Corvol P. Structure of human angiotensinogen gene. DNA 1989;8:87-99.

19. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71:169-180.

20. Jeunemaitre X, Rigat B, Charru A, Houot AM, Soubrier F, Corvol P. Sib pair linkage analysis of renin gene haplotypes in human essential hypertension. Hum Genet 1992;88:301-306.

21. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel JM. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992;1:72-75.

22. Bonnardeaux A, Davies E, Jeunemaitre X, et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994;24:63-69.

23. Caulfield M, Lavender P, Newell Price J, Kamdar S, Farrall M, Clark AJ. Angiotensinogen in human essential hypertension. Hypertension 1996;28:1123-1125.

24. Caulfield M, Lavender P, Newell Price J, et al. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest 1995;96:687-692.

25. Schmidt S, Sharma AM, Zilch O, et al. Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 1995;10:1145-1148.

26. Hingorani AD, Sharma P, Jia H, Hopper R, Brown MJ. Blood pressure and the M235T polymorphism of the angiotensinogen gene. Hypertension 1996;28:907-911.

27. Kiema TR, Kauma H, Rantala AO, et al. Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure. Hypertension 1996;28:1070-1075.

28. Borecki IB, Province MA, Ludwig EH, et al. Associations of candidate loci angiotensinogen and angio-tensin-converting enzyme with severe hypertension: The NHLBI Family Heart Study. Ann Epidemiol 1997;7:13-21.

29. Jeunemaitre X, Inoue I, Williams C, et al. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 1997;60:1448-1460.

30. Schunkert H, Hense HW, Gimenez-Roqueplo AP, et al. The angiotensinogen T235 variant and the use of antihypertensive drugs in a population-based cohort. Hypertension 1997;29:628-633.

31. Tiret L, Blanc H, Ruidavets JB, et al. Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. Projet d'Etude des Genes de l'Hypertension Arterielle Severe a moderee Essentielle. J Hypertens 1998;16:37-44.

32. Kunz R, Kreutz R, Beige J, Distler A, Sharma AM. Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension 1997;30:1331-1337.

33. Hata A, Namikawa C, Sasaki M, et al. Angiotensinogen as a risk factor for essential hypertension in Japan. J Clin Invest 1994;93:1285-1287.

34. Kamitani A, Rakugi H, Higaki J, et al. Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese. J Hum Hypertens 1994;8:521-524.

35. Iwai N, Shimoike H, Ohmichi N, Kinoshita M. Angiotensinogen gene and blood pressure in the Japanese population. Hypertension 1995;25:688-693.

36. Ishigami T, Umemura S, Tamura K, et al. Essential hypertension and 5' upstream core promoter region of human angiotensinogen gene. Hypertension 1997;30:1325-1330.

37. Bloem LJ, Foroud TM, Ambrosius WT, Hanna MP, Tewksbury DA, Pratt JH. Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites. Hypertension 1997;29:1078-1082.

38. Larson N, Hutchinson R, Boerwinkle E. Lack of association of 3 functional gene variants with hypertension in African Americans. Hypertension 2000;35:1297-1300.

39. Inoue I, Nakajima T, Williams CS, et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997;99:1786-1797.

40. Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD. Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. Physiol Genomics 2002;11:253-262.

41. Jain S, Tang X, Narayanan CS, et al. Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J Biol Chem 2002;277:36889-36896.

42. Choy B, Roberts SG, Griffin LA, Green MR. How eukaryotic transcription activators increase assembly of preinitiation complexes. Cold Spring Harb Symp Quant Biol 1993;58:199-203.

43. Choy B, Green MR. Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature 1993;366:531-536.

44. Ptashne M. 1997 Albert Lasker Award for Basic Medical Research. Control of gene transcription: an outline. Nat Med 1997;3:1069-1072.

45. Rosenfeld MG, Glass CK. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 2001;276:36,865-36,868.

46. Glass CK, Rosenfeld MG. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 2000;14:121-141.

47. LeVan TD, Bloom JW, Bailey TJ, et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001;167:5838-5844.

48. Spek CA, Greengard JS, Griffin JH, Bertina RM, Reitsma PH. Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. J Biol Chem 1995;270:24,216-24,221.

49. Farzaneh-Far A, Davies JD, Braam LA, et al. A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. J Biol Chem 2001;276:32466-32473.

50. Narayanan CS, Cui Y, Kumar A. DBP binds to the proximal promoter and regulates liver-specific expression of the human angiotensinogen gene. Biochem Biophys Res Commun 1998;251:388-393.

51. Zhao YY, Zhou J, Narayanan CS, Cui Y, Kumar A. Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene. Hypertension 1999;33:108-115.

52. Narayanan CS, Cui Y, Zhao YY, Zhou J, Kumar A. Orphan receptor Arp-1 binds to the nucleotide sequence located between TATA box and transcriptional initiation site of the human angiotensinogen gene and reduces estrogen induced promoter activity. Mol Cell Endocrinol 1999;148:79-86.

53. Yanai K, Nibu Y, Murakami K, Fukamizu A. A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene. J Biol Chem 1996;271:15981-15986.

54. Cui Y, Narayanan CS, Zhou J, Kumar A. Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression. Gene 1998;224:97-107.

55. Sherman CT, Brasier AR. Role of Signal Transducers and Activators of Transcription 1 and -3 in Inducible Regulation of the Human Angiotensinogen Gene by Interleukin-6. Mol Endocrinol 2001;15:441-457.

56. Narayanan CS, Cui Y, Kumar S, Kumar A. cAMP increases the expression of human angiotensinogen gene through a combination of cyclic AMP responsive element binding protein and a liver specific transcription factor. Mol Cell Biochem 2000;212:81-90.

57. Yanai K, Hirota K, Taniguchi-Yanai K, et al. Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor [In Process Citation]. J Biol Chem 1999;274:34,605-34,612.

58. Brasier AR, Han Y, Sherman CT. Transcriptional regulation of angiotensinogen gene expression. Vitam Horm 1999;57:217-247.

59. Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol 1992;12:1007-1020.

60. Patel YM, Yun JS, Liu J, McGrane MM, Hanson RW. An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice. J Biol Chem 1994;269:5619-5628.

61. Yan SF, Zou YS, Mendelsohn M, et al. Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia. J Biol Chem 1997;272:4287-4294.

62. Brinkmeier ML, Gordon DF, Dowding JM, et al. Cell-specific expression of the mouse glycoprotein hormone alpha-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells. Mol Endocrinol 1998;12:622-633.

63. Cvetkovic B, Yang B, Williamson RA, Sigmund CD. Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem 2000;275:1073-1078.

64. Zhu X, Chang YP, Yan D, et al. Associations between hypertension and genes in the renin-angiotensin system. Hypertension 2003;41:1027-1034.

65. Casari G, Barlassina C, Cusi D, et al. Association of the alpha-adducin locus with essential hypertension. Hypertension 1995;25:320-326.

66. Bray MS, Krushkal J, Li L, et al. Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation 2000;101:2877-2882.

67. Dong Y, Zhu H, Sagnella GA, et al. Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. Hypertension 1999;34:1193-1196.

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