Platelet Interactions

Fondaparinux at concentrations of 1-100 pg/ml does not cause platelet aggregation, or influence platelet aggregation induced by epinephrine, ADP, collagen or arachidonic acid (154).

Fondaparinux does not induce in vitro platelet aggregation or activation in the presence of heparin antibody obtained from patients clinically diagnosed with HIT (154,160-162). However, data from the clinical trials in orthopedic surgery reveal that platelet counts < 100,000 pi-1 do occur with fondaparinux treatment. In the fondaparinux groups 2.7% and 4.9% of patients vs 3.7% and 5.3% of patients treated with enoxaparin developed thrombocytopenia (147,148).

0 0

Post a comment