The Cancer Genome Anatomy Project Cgap

The Cancer Genome Anatomy Project (CGAP Lal et al., 1999 Lash et al., 2000 Riggins and Strausberg, 2001 Schaefer et al., 2001 Strausberg et al., 1997, 2000) is a project of the National Cancer Institute (NCI). Their main objective is to decipher the molecular mechanism of cancer. For this goal, information is gathered from different resources such as gene expression data, aberrations of chromosomes, gene variation and biochemical pathways. CGAP collaborates with the National Centre for...

The NCI60 Cell Line and GNF Gene Expression Atlas Ratios

The UCSC Human Genome Browser hosts two public domain microarray data tracks. The NCI60 cell line track presents data from a cDNA microarray experiment to assay the expression of more than 8000 genes among 60 tumour-derived cell lines used in the National Cancer Institute's (NCI) anti-cancer drug screens (Ross et al, 2000 http genome-www.stanford.edu nci60 ). The GNF track shows expression data generated from 46 human tissues and cell lines by the Genomics Institute of the Novartis Research...

ENU Mutagenesis Centres

Several public large-scale ENU mutagenesis projects are already underway and are providing new models for the study of disease and gene function to the community Brown and Nolan, 1998 De Angelis et al, 2000 Justice et al, 1999 Nolan et al., 2000 Table 6.1 . Some of the mutagenesis centres are working in several disease areas to identify new mutants including the ENU Mutagen-esis Programme at Harwell the RIKEN Mouse Functional Genomics Group http www.gsc.riken.go.jp Mouse , and the GSF ENU Mouse...

The Mitelman Chromosome Abberations

Cytogenetic studies over the past few decades have revealed clonal chromosomal aberrations in over 100,000 human neoplasms. Many of these have been characterized at the molecular level, revealing previously unknown genes that may be closely associated with tumourigenesis. Information on chromosome changes in neoplasia has grown rapidly, making it difficult to identify all recurrent chromosomal aberrations. The Mitelman Map of Chromosome Aberrations in Cancer Mitelman et al., 1997 was first...