Hyaluronan in Emphysema

Evidence relating HA to emphysema is accumulating. Konno et al. (114) found HA to be decreased in emphysematous lungs. Data from animal models show that HA is involved in cigarette smoke-induced emphysema and in elastase-induced emphysema. Guinea pigs exposed to tobacco smoke have reduced levels of lung HA (115). Cantor et al. (116) showed that instillment of hyaluronidase and the addition of 60% oxygen, which is a non-toxic concentration of oxygen, produced air-space enlargement. They also showed that prior hyaluronidase treatment increased the effect of elastase instillment (117), an observation that was confirmed by Murakami et al. (118). Further, HA protected elastin fibers in vitro and lead to a decrease in air-space enlargement caused by elastase instillment in vivo (119).

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