Depolymerization Of Hyaluronic Acid By Autoxidants And Radiations

1. Murray JF. The Normal Lung: The Basis for Diagnosis and Treatment of Pulmonary Disease. Philadelphia: W.B. Saunders, 1976; 46-48.

2. Weibel ER. Morphological basis of alveolar-capillary gas exchange. Physiol Rev 1973; 53(2):419-495.

3. Purves WK, Orians GH, Heller HC. Life, the Science of Biology, 4th ed. Sunderland: Sinauer Associates, 1995; 944.

4. Bray BA. The role of hyaluronan in the pulmonary alveolus. J Theor Biol 2001; 210:121-130.

5. Pasquali-Ronchetti I, Quaglino D, Mori G, Bacchelli B, Ghosh P. Hyaluronan-phospholipid interactions. J Struct Biol 1997; 120:1-10.

6. Termeer C, Sleeman JP, Simon JC. Hyaluronan—magic glue for the regulation of the immune response? Trends Immunol 2003; 24:112-114.

7. Turino GM, Cantor JO. Hyaluronan in respiratory injury and repair. Am J Respir Crit Care Med 2003; 167:1169-1175.

8. Bhattacharya J, Cruz T, Bhattacharya S, Bray BA. Hyaluronan affects extravascular water in lungs of unanesthetized rabbits. J Appl Physiol 1989; 66: 2595-2599.

9. Nettelbladt O, Tengblad A, Hallgren R. Lung accumulation of hyaluronan parallels pulmonary edma in experimental alveolitis. Am J Physiol 1989; 257: L379-L384.

10. Green SJ, Tarone G, Underhill CB. Distribution of hyaluronate and hyaluronate receptors in the adult lung. J Cell Sci 1988; 89:145-156.

11. Hernnas J, Nettelbladt O, Bjermer L, Sarnstrand B, Malmstrom A, Hallgren R. Alveolar accumulation of fibronectin and hyaluronan precedes bleomycin-induced pulmonary fibrosis in the rat. Eur Respir J 1992; 5:404-410.

12. Bjermer L, Lundgren R, Hallgren R. Hyaluronan and type III procollagen peptide concentrations in bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis. Thorax 1989; 44:126-131.

13. Bray BA, Sampson PM, Osman M, Giandomenico A, Turino GM. Early changes in lung tissue hyaluronan (hyaluronic acid) and hyaluronidase in bleomycin-induced alveolitis in hamsters. Am Rev Respir Dis 1991; 143:284-288.

14. Nettelbladt O, Hallgren R. Hyaluronan (hyaluronic acid) in bronchoalveolar lavage fluid during the development of bleomycin-induced alveolitis in the rat. Am Rev Respir Dis 1989; 140:1028-1032.

15. Nettelbladt O, Bergh J, Schenholm M, Tengblad A, Hallgren R. Accumulation of hyaluronic acid in the alveolar interstitial tissue in bleomycin-induced alveolitis. Am Rev Respir Dis 1989; 139:759-762.

16. Teder P, Nettelbladt O, Heldin P. Characterization of the mechanism involved in bleomycin-induced increased hyaluronan production in rat lung. Am J Respir Cell Mol Biol 1995; 12:181-189.

17. Teder P, Heldin P. Mechanism of impaired local hyaluronan turnover in bleomycin-induced lung injury in rat. Am J Respir Cell Mol Biol 1997; 17: 376-385.

18. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM, Noble PW. Resolution of lung inflammation by CD44. Science 2002; 296:155-158.

19. Jacobson A, Brinck J, Briskin MJ, Spicer AP, Heldin P. Expression of human hyaluronan synthases in response to external stimuli. Biochem J 2000; 348:29-35.

20. Li Y, Rahmanian M, Widstrom C, Lepperdinger G, Frost GI, Heldin P. Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expression. Am J Respir Cell Mol Biol 2000; 23(3):411-418.

21. Fraser JRE, Laurent TC, Laurent UBG. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med 1997; 242:27-33.

22. Holmes MWA, Bayliss MT, Muir H. Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem J 1988; 250:435-441.

23. Cleland RL, Wang JL. Ionic polysaccharides. III. Dilute solution properties of hyaluronic acid fractions. Biopolymers 1970; 9:799-810.

24. Laurent TC. Structure of hyaluronic acid. In: Balazs EA, ed. Chemistry and Molecular Biology of the Intercellular Matrix. London: Academic Press, 1970: 703-732.

25. Heatley F, Scott JE. A water molecule participates in the secondary structure of hyaluronan. Biochem J 1988; 254:489-493.

26. Coleman PJ, Scott D, Mason RM, Levick JR. Role of hyaluronan chain length in buffering interstitial flow across synovium in rabbits. J Physiol 2000; 526: 425-434.

27. Turner RE, Lin P, Cowman MK. Self-association of hyaluronate segments in aqueous NaCl solution. Arch Biochem Biophys 1988; 265(2):484-495.

28. Scott JE, Cummings C, Brass A, Chen Y. Secondary and tertiary structures of hyaluronan in aqueous solution, investigated by rotary shadowing-electron microscopy and computer simulation. Biochem J 1991; 274:699-705.

29. Cowman MK, Li M, Balazs EA. Tapping mode atomic force microscopy of hyaluronan: extended and intramolecularly interacting chains. Biophys J 1998; 75: 2030-2037.

30. Brewton RG, Mayne R. Mammalian vitreous humor contains networks of hyaluronan molecules: electron microscopic analysis using the hyaluronan-binding region (G1) of aggrecan and link protein. Exp Cell Res 1992; 198:237-249.

31. Scott JE, Heatley F. Hyaluronan forms specific stable tertiary structures in aqueous solution: a 13C NMR study. Proc Natl Acad Sci USA 1999; 96:4850-4855.

32. Hardingham TE, Muir H. The specific interaction of hyaluronic acid with cartilage proteoglycans. Biochim Biophys Acta 1972; 279:401-405.

33. Heinegard D, Hascall VC. Aggregation of cartilage proteoglycans. III. Characteristics of the proteins isolated from trypsin digests of aggregates. J Biol Chem 1974; 249:4250-4256.

Caterson B, Baker J. The interaction of link proteins with proteoglycan monomers in the absence of hyaluronic acid. Biochem Biophys Res Commun 1978; 80: 496-503.

Watanabe H, Cheung SC, Itano N, Kimata K, Yamada Y. Identification of hyaluronan-binding domains of aggrecan. J Biol Chem 1997; 272:28057-28065. Hardingham TE, Muir H. Binding of oligosaccharides of hyaluronic acid to proteoglycans. Biochem J 1973; 135:905-908.

Calvo JC, Gandjbakhche AH, Nossal R, Hascall VC, Yanagishita M. Rheological effects of the presence of hyaluronic acid in the extracellular media of differentiated 3T3-L1 preadipocyte cultures. Arch Biochem Biophys 1993; 302:468-475. LeBaron RG, Zimmermann DR, Ruoslahti E. Hyaluronate binding properties of versican. J Biol Chem 1992; 267:10003-10010.

Matsumoto K, Shionyu M, Go M, Shimizu K, Shinomura T, Kimata K, Watanabe H. Distinct interaction of versican/PG-M with hyaluronan and link protein. J Biol Chem 2003; 278:41205-41212.

Krusius T, Gehlsen KR, Ruoslahti E. A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences. J Biol Chem 1987; 262:13120-13125.

Zimmermann DR, Ruoslahti E. Multiple domains of the large fibroblast proteoglycan, versican. EMBO J 1989:2975-2981.

Isogai Z, Aspberg A, Keene DR, Ono RN, Reinhardt DP, Sakai LY. Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. J Biol Chem 2002; 277:4565-4572.

Chen L, Yang BL, Wu Y, Yee A, Yang BB. G3 domains of aggrecan and PG-M/ versican form intermolecular disulfide bonds that stabilize cell-matrix interaction. Biochemistry 2003; 42:8332-8341.

Passi A, Negrini D, Albertini R, DeLuca G, Miserocchi G. Involvement of lung interstitial proteoglycans in development of hydraulic- and elastase-induced edema. Am J Physiol 1998; 275:L631-L635 (Lung Cell Mol Physiol 19). Forrester JV, Balazs EA. Inhibition of phagocytosis by high molecular weight hyaluronate. Immunology 1980; 40:435-446.

West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science 1985; 228:1324-1326.

West DC, Kumar S. The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity. Exp Cell Res 1989; 183:


Slevin M, Krupinski J, Kumar S, Gaffney J. Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation. Lab Investig 1998; 78:987-1003.

Termeer CC, Hennies J, Voith U, Ahrens T, Weiss JM, Prehm P, Simon JC. Oligosaccharides of hyaluronan are potent activators of dendritic cells. J Immunol 2000; 165:1863-1870.

Zeng C, Toole BP, Kinney SD, Kuo J-W, Stamenkovic I. Inhibition of tumor growth in vivo by hyaluronan oligomers. Int J Cancer 1998; 77:396-401. McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, Bao C, Noble PW. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Investig 1996; 98: 2403-2413.

52. Noble PW, McKee CM, Cowman M, Shin HS. Hyaluronan fragments activate an NF-kB/I-kBalpha autoregulatory loop in murine macrophages. J Exp Med 1996; 183:2373-2378.

53. Horton MR, Burdick MD, Strieter RM, Bao C, Noble PW. Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages. J Immunol 1998; 160:3023-3030.

54. Kreil G. Hyaluronidases—a group of neglected enzymes. Protein Sci 1995; 4: 1666-1669.

55. Frost GI, Csoka T, Stern R. The hyaluronidases: a chemical, biological, and clinical overview. Trends Glycosci Glycotechnol 1996; 8:419-434.

56. Frost GI, Csoka TB, Wong T, Stern R. Purification, cloning, and expression of human plasma hyaluronidase. Biochem Biophys Res Commun 1997; 236: 10-15.

57. Lepperdinger G, Strobl B, Kreil G. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. J Biol Chem 1998; 273:22466-22470.

58. Sampson PM, Rochester CL, Freundlich B, Elias JA. Cytokine regulation of human lung fibroblast hyaluronan (hyaluronic acid) production. Evidence for cytokine-regulated hyaluronan (hyaluronic acid) degradation and human lung fibroblast-derived hyaluronidase. J Clin Investig 1992; 90:1492-1503.

59. Rai SK, Duh F-M, Vigdorovich V, Danilkovitch-Miagkova A, Lerman MI, Miller AD. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci USA 2001; 98: 4443-4448.

60. Stabellini G, Calvitti M, Baroni T, Marinucci L, Calastrini C, Carinci P, Becchetti E. Glycosidases during chick embryo lung development and their colocalization with proteoglycans and growth factors. Eur J Histochem 2002; 46:41-52.

61. Schmid K, Grundboeck-jusco J, Kimura A, Tschopp FA, Zollinger R, Binette JP, Lewis W, Hayashi S. The distribution of the glycosaminoglycans in the anatomic components of the lung and the changes in concentration of these macromolecules during development and aging. Biochim Biophys Acta 1982; 716:178-187.

62. Thet LA, Howell AC, Han G. Changes in lung hyaluronidase activity associated with lung growth, injury and repair. Biochem Biophys Res Commun 1983; 117: 71 -77.

63. McNeil JD, Wiebkin OW, Betts WH, Cleland LG. Depolymerisation products of hyaluronic acid after exposure to oxygen-derived free radicals. Ann Rheum Dis 1985; 44:780-789.

64. Al-Assaf S, Navaratnam S, Parsons BJ, Phillips GO. Chain scission of hyaluronan by peroxynitrite. Arch Biochem Biophys 2003; 411:73-82.

65. Matsumura G, Herp A, Pigman W. Depolymerization of hyaluronic acid by autoxidants and radiations. Radiation Res 1966; 28:735-752.

66. Moore JS, Phillips GO, Davies JV. Reactions of connective tissue and related polyanions with hydrated electrons and hydroxyl radicals. Carbohydr Res 1970; 12:253-260.

67. Harris MJ, Herp A, Pigman W. Depolymerization of polysaccharides through the generation of free radicals at a platinum surface: a novel procedure for the controlled production of free-radical oxidations. Arch Biochem Biophys 1971; 142:615-622.

Babior BM, Kipnes RS, Curnutte JT. Biological defense mechanisms: the production by leukocytes of superoxide, a potential bactericidal agent. J Clin Investig 1973; 52:741-744.

Goldstein IM, Roos D, Kaplan HB, Weissmann G. Complement and immuno-globulins stimulate superoxide production by human leukocytes independently of phagocytosis. J Clin Investig 1975; 56:1155-1163.

Johnston RB, Lehmeyer JE, Guthrie LA. Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G. J Exp Med 1976; 143: 1551-1556.

McCall TB, Broughton-Smith NK, Palmer RMJ, Whittle BJR, Moncada S. Synthesis of nitric oxide from L-arginine by neutrophils: release and interaction with superoxide anion. Biochem J 1989; 261:293-296.

Marletta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 1988; 27:8706-8711.

Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87:1620-1624. Green SP, Baker MS, Lowther DA. Depolymerization of synovial fluid hyaluronic acid (HA) by the complete myeloperoxidase (MPO) system may involve the formation of a HA-MPO ionic complex. J Rheum 1990; 17:1670-1675. Greenwald RA, Moy WW. Effect of oxygen-derived free radicals on hyaluronic acid. Arthritis Rheum 1980; 23:455-463.

Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TAE, Gaston B. Endogenous airway acidification: implications for asthma pathophysiology. Am J Respir Crit Care Med 2000; 161:694-699.

McKee CM, Lowenstein CJ, Horton MR, Wu J, Bao C, Chin BY, Choi AMK, Noble PW. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kB-dependent mechanism. J Biol Chem 1997; 272:8013-8018.

Weibel ER, Gil J. Electron microscopic demonstration of an extracellular duplex lining layer of alveoli. Respir Physiol 1968; 4:42-57.

Manabe T. Freeze-fracture study of alveolar lining layer in adult rat lung. J Ultrastruct Res 1979; 69:86-97.

Schurch S, Green FHY, Bachofen H. Formation and structure of surface films: captive bubble surfactometry. Biochim Biophys Acta 1998; 1408:180-202. Bastacky J, Lee CYC, Goerke J, Koushafar H, Yager D, Kenaga L, Speed TP, Chen Y, Clements JA. Alveolar lining layer is thin and continuous: low-temperature scanning electron microscopy of rat lung. J Appl Physiol 1995; 79: 1615-1628.

Halter JM, Steinberg JM, Schiller HJ, DaSilva M, Gatto LA, Landas S, Nieman GF. Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med 2003; 167:1620-1626.

Phelps DS, Floros J. Localization of surfactant protein synthesis in human lung by in situ hybridization. Am Rev Respir Dis 1988; 137:939-942. Whitsett JA, Glasser SW. Regulation of surfactant protein gene transcription. Biochim Biophys Acta 1998; 1408:303-311.

85. Sahu SC, Tanswell AK, Lynn WS. Isolation and characterization of glyco-saminoglycans secreted by human foetal lung type II pneumocytes in culture. J Cell Sci 1980; 42:183-188.

86. Skinner SJM, Post M, Torday JS, Stiles AD, Smith BT. Characterization of proteoglycans synthesized by fetal rat lung type II pneumonocytes in vitro and the effects of cortisol. Exp Lung Res 1987; 12:253-264.

87. Creuwels LAJM, van Golde LMG, Haagsman HP. The pulmonary surfactant system: biochemical and clinical aspects. Lung 1997; 175:1-39.

88. Nadesalingam J, Bernal AL, Dodds AW, Willis AC, Mahoney DJ, Day AJ, Reid KB, Palaniyar N. Identification and characterization of a novel interaction between pulmonary surfactant protein D and decorin. J Biol Chem 2003; 278: 25678-25687.

89. Wu H, Kuzmenko A, Wan S, Schaffer L, Weiss A, Fisher JH, Kim KS, McCormack FX. Surfactant proteins A and D inhibit the growth of gram-negative bacteria by increasing membrane permeability. J Clin Investig 2003; 111: 1589-1602.

90. Goerke J. Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta 1998; 1408:79-89.

91. Perez-Gil J, Keough KMW. Interfacial properties of surfactant proteins. Biochim Biophys Acta 1998; 1408:203-217.

92. Maniscalco WM, Campbell MH. Alveolar type II cells synthesize hydrophobic cell-associated proteoglycans with multiple core proteins. Am J Physiol 1992; 263:L348-L356.

93. Bray BA, Hsu W, Turino GM. Lung hyaluronan as assayed with a biotinylated hyaluronan-binding protein. Exp Lung Res 1994; 20:317-330.

94. Sampson PM, Heimer R, Fishman A. Detection of glycosaminoglycans at the one-nanogram level by 125 I-cytochrome c. Anal Biochem 1985; 151:304-308.

95. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simons E. Oligosaccharides of hyaluronan activate dendritic cells via Toll-like receptor 4. J Exp Med 2002; 195:99-111.

96. Mummert ME, Mummert D, Edelbaum D, Hui F, Matsue H, Takashima A. Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation. J Immunol 2002; 169:4322-4331.

97. Venge P, Pedersen B, Hakansson L, Hallgren R, Lindblad G, Dahl R. Subcutaneous administration of hyaluronan reduces the number of infectious exacerbations in patients with chronic bronchitis. Am J Respir Crit Care Med 1996; 153:312-316.

98. Wright RR. Elastic tissue of normal and emphysematous lungs. A tridimensional histologic study. Am J Pathol 1961; 39:355-367.

99. Karlinsky J, Fredette J, Davidovits G, Catanese A, Snider R, Faris B, Snider GL, Franzblau C. The balance of lung connective tissue elements in elastase-induced emphysema. J Lab Clin Med 1983; 102:151-162.

100. Chrzanowski P, Keller S, Cerreta J, Mandl I, Turino GM. Elastin content of normal and emphysematous lung parenchyma. Am J Med 1980; 69:351-359.

101. Janoff A. Elastases and emphysema: Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985; 132:417-433.

102. Fujita J, Nelson NL, Daughton DM, Dobry CA, Spurzem JR, Irino S, Rennard SI. Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am Rev Respir Dis 1990; 142:57-62.

Laurell C-B, Eriksson S. The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency. Scand J Clin Lab Investig 1963; 15: 132-140.

Beatty K, Matheson N, Travis J. Kinetic and chemical evidence for the inability of oxidized alpha 1-proteinase inhibitor to protect lung elastin from elastolytic degradation. Hoppe-Seyler Z Physiol Chem 1984; 365:731-736. Weitz JI, Crowley KA, Landman SL, Lipman BI, Yu J. Increased neutrophil elastase activity in cigarette smokers. Ann Intern Med 1987; 107:680-682. Churg A, Wang RD, Xie C, Wright JL. Alpha-1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2003; 168: 199-207.

Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997; 277:2002-2004.

Zheng T, Zhu Z, WangZ, Homer RJ, MaB, Riese RJ Jr, Chapman HAJ, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metallo-proteinase- and cathepsin-dependent emphysema. J Clin Investig 2000; 106: 1081-1093.

Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA Jr, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000; 192:1587-1599.

D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992; 71: 955-961.

Shiomi T, Okada Y, Foronjy R, Schiltz J, Jaenish R, Krane S, D'Armiento J. Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp Lung Res 2003; 29:1-15. Foronjy RF, Okada Y, Cole R, D'Armiento J. Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung. Am J Physiol Lung Cell Mol Physiol 2003; 284:L727-L737.

Imai K, Dalal SS, Chen ES, Downey R, Schulman LL, Ginsburg M, D'Armiento J. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. Am J Respir Crit Care Med 2001; 163: 786-791.

Konno K, Arai H, Motomiya M, Nagai H, Ito M, Sato H, Satoh K. A biochemical study on glycosaminoglycans (mucopolysaccharides) in emphysematous and in aged lungs. Am Rev Respir Dis 1982; 126:797-801.

Dabrowski R, Maslinski C. Collagen, glycosaminoglycans and histamine in lungs of guinea pigs exposed chronically to cigarette smoke. Bull Acad Pol Sci Biol 1975; 23:125-128.

Cantor JO, Cerreta JM, Armand G, Keller S, Turino GM. Pulmonary air-space enlargement induced by intratracheal instillment of hyaluronidase and concomitant exposure to 60% oxygen. Exp Lung Res 1993; 19:177-192. Cantor JO, Cerreta JM, Keller S, Turino GM. Modulation of airspace enlargement in elastase-induced emphysema by intratracheal instillment of hyaluronidase and hyaluronic acid. Exp Lung Res 1995; 21:423-436.

Murakami H, Yoshida M, Aritomi T, Shiraishi M, Ishibashi M, Watanabe K. Effects of hyaluronidase on procine pancreatic elastase-induced lung injury. J Jpn Respir Soc 1998; 36:577-584.

119. Cantor JO, Shteyngart B, Cerreta JM, Liu M, Armand G, Turino GM. The effect of hyaluronan on elastic fiber injury in vitro and elastase-induced airspace enlargement in vivo. Proc Soc Exp Biol Med 2000; 225:65-71.

120. van de Lest CHA, Versteeg EMM, Veerkamp JH, van Kuppevelt TH. Digestion of proteoglycans in porcine pancreatic elastase-induced emphysema in rats. Eur Respir J 1995; 8:238-245.

121. van Straaten JFM, Coers W, Noordhoek JA, Huitema S, Flipsen JTM, Kauffman HF, Timens W, Postma DS. Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema. Mod Pathol 1999; 12: 697-705.

122. Visconti RP, Barth JL, Keeley FW, Little CD. Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development. Matrix Biol 2003; 22:109-121.

123. Kozel BA, Wachi H, Davis EC, Mecham RP. Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. J Biol Chem 2003; 278:18491-18498.

124. Merrilees MJ, Lemire JM, Fischer JW, Kinsella MG, Braun KR, Clowes AW, Wight TN. Retrovirally mediated overexpression of versican v3 by arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointima after vascular injury. Circ Res 2002; 90:481-487.

125. Baccarani-Contri M, Vincenzi D, Cicchetti F, Mori G, Pasquali-Ronchetti I. Immunocytochemical localization of proteoglycans within normal elastin fibers. Eur J Cell Biol 1990; 53:305-312.

126. Vaccaro CA, Brody JS. Ultrastructural localization and characterization of proteoglycans in the pulmonary alveolus. Am Rev Respir Dis 1979; 120:901-910.

127. van Kuppevelt THMSM, Cremers FPM, Domen JGW, van Beuningen HM, van den Brule AJC, Kuyper CMA. Ultrastructural localization and characterization of proteoglycans in human lung alveoli. Eur J Cell Biol 1985; 36:74-80.

128. McDevitt CA, Marcelino J, Tucker L. Interaction of intact type VI collagen with hyaluronan. FEBS Lett 1991; 294:167-170.

129. Kielty CM, Whittaker SP, Grant ME, Shuttleworth CA. Type VI collagen microfibrils: evidence for a structural association with hyaluronan. J Cell Biol 1992; 118:979-990.

130. Coleman PJ. Evidence for a role of hyaluronan in the spacing of fibrils within collagen bundles in rabbit synovium. Biochim Biophys Acta 2002; 1571: 173-182.

131. Scott JE. The chemical morphology of the vitreous. Eye 1992; 6:553-555.

132. McDevitt CA, Beck GJ, Ciunga MJ, O'Brien J. Cigarette smoke degrades hyaluronic acid. Lung 1989; 167:237-245.

133. Pecora LJ, Manne WR, Baum GL, Feldman DP, Recavarren S. Biochemical study of ground substance in normal and emphysematous lungs. Am Rev Respir Dis 1967; 95:623-630.

134. Rao NV, Kennedy TP, Rao G, Ky N, Hoidal JR. Sulfated polysaccharides prevent human leukocyte elastase-induced acute lung injury and emphysema in hamsters. Am Rev Respir Dis 1990; 142:407-412.

135. DeAngelis PL, Oatman LC, Gay DF. Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. J Biol Chem 2003; 278:35199-35203.

Chemistry and Biology of Hyaluronan H.G. Garg and C.A. Hales (editors) © 2004 Elsevier Ltd. All rights reserved.

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