Imbalance Between Stimulatory And Inhibitory B7 Family Molecules

B7-H1 in the Tumor Microenvironment B7-H1 (PD-L1) is a B7 family member with approximately 25 homology between B7.1, B7.2, and B7-H1 (Choi et al, 2003 Dong et al., 1999 Tamura et al., 2001). IL-10 and VEGF stimulate B7-H1 expression in myeloid DCs present in ovarian tumors and their draining lymph nodes. A significant fraction of tumor-associated T cells are regulatory T cells (CD4+CD25+FOXP3+) (Curiel et al., 2004b) (see following paragraphs), which express PD-1, the ligand for B7-H1 (Chen,...

Chemotherapy Regimens

As of this writing, the standard of care for cancer patients involves combinatorial regimens that often include agents belonging to separate classes of cytotoxic chemotherapy described in this chapter. Doses and scheduling have been determined over many years of experience and through use of evidence-based medicine through trial and error experiments based on the inherently empirical way , classical cytotoxic agents have been developed i.e., without direct reference to molecular mechanisms ....

Parts Of The Book

Part I of the book introduces principles of cancer immunobiology. In Chapter 2, the central concept of immunoediting is introduced. This fundamental process has three parts, termed immunosurveillance, immune equilibrium, and immune escape, which lead to control, stasis, or outgrowth of a malignancy. Immunoediting starts with the immune recognition and destruction of cells that have acquired genetic and epigenetic alterations characteristic of tumor cells, but at the same time, the selective...

Cancer Immune Surveillance

In the early twentieth century, Ehrlich first proposed the existence of immune surveillance for eradicating nascent transformed cells before they are clinically detected Ehrlich, 1909 . Almost 50 years later, Burnet and Thomas postulated that the control of nascent transformed cells may represent the actions of an ancient immune system, which played a critical role in preventing malignant transformation Burnet, 1957 . The idea was supported by experimental results showing strong immune-mediated...

Masahisa Jinushi And Glenn Dranoff

Adaptive Immunity in Immunosurveillance B. Targets of Antitumor T Cell Responses C. Antitumor Effector Mechanisms V. The Interplay of Innate and Adaptive Antitumor Immunity VI. Conclusion The interplay of innate and adaptive antitumor immunity dictates the intensity and outcome of the endogenous anticancer response. Stress-induced molecules on tumor cells trigger innate immune reactions, whereas the processing and presentation of tumor-associated antigens...