Complement Coagulation

Fig. 10.4. Interrelationship of the coagulation system and complement. The complement and coagulation pathways are intimately linked via the plasma protein kallikrein, the enzymatic form of the zymogen, prekallikrein. The conversion of prekallikrein to kallikrein follows the enzymatic action of activated Factor XII, the initiator of the contact pathway of intrinsic coagulation. Substrates for kallikrein include the complement component C5, as well as kininogen, a protein that serves as a cofactor in the activation of Factor XII. Additionally, kallikrein, in the presence of calcium and magnesium, aggregates and activates neutrophils.

Fig. 10.4. Interrelationship of the coagulation system and complement. The complement and coagulation pathways are intimately linked via the plasma protein kallikrein, the enzymatic form of the zymogen, prekallikrein. The conversion of prekallikrein to kallikrein follows the enzymatic action of activated Factor XII, the initiator of the contact pathway of intrinsic coagulation. Substrates for kallikrein include the complement component C5, as well as kininogen, a protein that serves as a cofactor in the activation of Factor XII. Additionally, kallikrein, in the presence of calcium and magnesium, aggregates and activates neutrophils.

Kininogen (cofactor)

Activates

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