1

Initial transcription

*CD19 is expressed on the cell surface of pre-B, immature B and mature B cells (not shown)

• DNA gene rerarrangement of n heavy chain

• Allelic exclusion

• Initial transcription of n heavy chain t |x associates with \|r light chains to form pre-BCR

• Pre-BCR is expressed on the cell surface with CD79a/CD79b t DNA gene rearrangement of light chains, kappa (k), or lambda (X).

Initial transcription of kappa (k) or lambda (X) light chain

Association of k or X with n to form BCR

BCR expressed on the cell surface with CD79a/CD79b

• Down regulation of y light chain

• Down regulation of pre-BCR Tolerance induction

• Alternative splicing

• Surface expression of both IgD and IgM**

• Surface expression of adhesion molecules **

• Surface expression of CD40, CD21, CD81, and CD45 **

Fig. 7.4. Antigen independent B-cell differentiation in the bone marrow: B-cell differentiation in the bone marrow is characterized by expression or silencing of distinct sets of genes at discrete stages defined as "pro-B cell, pre-B cell, immature B cell, and mature B cell" stages.

Rearranged DNA Encoding the Heavy Chain

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