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Memory Professor System Summary


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Author: Kit Stevenson
Official Website: memoryprofessor.com
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5 Minute Learning Machine

Jack Singer the author of The advancement of learning guide, has also been involved in writing other books about certain tricks to learn in life. The product is a comprehensive, self-paced, user-friendly, enhanced-reading and advanced learning techniques program. The product is a program that gives you a chance to liberate the undiscovered brilliance unlocked inside of you. Get to experience a real phenomenal memory. This product does not entail techniques or a mechanistic experiment that reveals the study of and development of systems for improving and assisting the memory. The list goes on about what pending problems you can solve with this program. These problems include; Math problems- you can thus be able to solve a whole world of math-mystery. It entails the simple secret of how to avoid 20 percent of all math errors worth your time! business-mystery, and financial mysteries. All opened up from one simple change in your work habits. Minimal concentration do you wish to develop total concentration?. The guide issues you with a simple routine to help you get down to work instantly. You can then absorb huge amounts of information easily even in a room filled with howling children. The package comes in form of an e-book, acquired online. It is intended for men and women of ages. Read more here...

5 Minute Learning Machine Summary

Contents: Ebook
Author: Jack Singer
Official Website: www.5minutelearningmachine.com
Price: $27.00

Tips For A Clear And Accurate Writeup

You should write the record as soon as possible, before the data fade from your memory. At first, you will probably prefer to take notes when talking with the patient. As you gain experience, however, work toward recording the Present Illness, the Past Medical History, the Family History, the Personal and Social History, and the Review of Systems in final form during the interview. Leave spaces for filling in details later. During the physical examination, make note immediately of specific measurements, such as blood pressure and heart rate. On the other hand, recording multiple items interrupts the flow of the examination, and you will soon learn to remember your findings and record them after you have finished.

Higherlevel Cognitive Functions

Speech and language processing are largely intact in older adults under normal conditions, although processing time may be somewhat slower than in young adults. In fact, there is evidence that discourse skills actually improve with age. Older people often tell well-structured elaborate narratives that are judged by others to be more interesting than those told by young 46 . They usually have more extensive vocabularies and although they exhibit the occasional word-finding difficulty, older adults are easily able to provide circumlocutions to mask the problem. They are skilled conversationalists and appear to have few difficulties in processing ongoing speech. As noted above, however, some older adults have hearing loss and so, in conversational settings, may be required to interpret a weak or distorted acoustic signal. Even under these conditions, older people seem able to maintain good levels of comprehension by effectively using context to interpret the message 47 . Nevertheless,...

Category Representations of Humans versus Nonhuman Animals Exemplars versus Prototypes

In addition, it is important to mention that the simple computational model that could simulate the cat versus dog asymmetry (i.e., a model that embodies only a short-term memory for within-task learning) could not simulate the human versus nonhuman animal asymmetry. However, a model that incorporates a long-term memory structure along with previous training on humans can simulate the human versus nonhuman animal asymmetry (Mermillod, French, Quinn, & Mareschal, 2004). In particular, it was shown that a dual-network connectionist architecture that incorporates both bottom-up (i.e., short-term memory) and top-down (i.e., long-term memory) processing was sufficient to account for the empirical results on categorization of humans versus nonhuman animals obtained with the infants. The dual-network memory model was able to reproduce the results of Quinn and Eimas (1998) because the LTM network contained a representation of humans that influenced processing in the STM network. In...

Future Instrumentation Principles In Clinical Chemistry

Miniaturization of analyzers has continued since automation was first introduced in the 1950s. Ion-selective electrodes have become smaller and can now be placed in hand-held devices. As memory capacity expands, microprocessors and computers are becoming smaller in size. Minute electronic components called microchip devices have been developed to carry out electrophoresis separation of proteins with immunoassay quantification.6 Work is underway to create even smaller electronic devices that help to perform clinical diagnostic testing. The term nanotechnology is used to describe many types of devices in which the characteristic dimensions are very small (< 1000 nm). Future trends in clinical chemistry testing will include the use of smaller and smaller diagnostic components.7

The Normal Adult Brain

In a series of studies on experimental animals, clear evidence has been provided that mental capacities decrease with aging. Using the holeboard test system which discriminates long-term memory (refernce memory) and short-term memory (working memory), a significant reduction (> 50 ) in both memory capacities was found (Plaschke et al 1999 see also references herein).

Management Of Adverse Reactions

Mild and sometimes even severe episodes ('bad trips') can be managed by reassurance including talk, 'talking the patient down', and physical contact, e.g. hand holding (LSD and mescaline). The objective is to help patients relate their experience to reality and to appreciate that the mental experiences are drug-induced and will abate. Because short-term memory is disrupted the treatment can be very time-consuming since therapists cannot absent themselves without risking relapse. But with phencyclidine such intervention may have the opposite effect, i.e. overstimulation. It is therefore appropriate to sedate all anxious or excited subjects with diazepam (or haloperidol). With sedation the 'premorbid ego' may be rapidly re-established.

Whole Bone Marrow Transplants In An Hd Model

Bilateral injections of QA caused significant working memory impairment (*p < 0.05 relative to sham-operated control rats) during the first 2 wk of testing in the RAWM spatial learning task. However, QA-treated rats that received transplants of suspended WBM cells were protected from these QA-induced deficits and had significantly fewer working memory errors ( p < 0.05 relative to rats receiving QA without transplants). Fig. 1. Bilateral injections of QA caused significant working memory impairment (*p < 0.05 relative to sham-operated control rats) during the first 2 wk of testing in the RAWM spatial learning task. However, QA-treated rats that received transplants of suspended WBM cells were protected from these QA-induced deficits and had significantly fewer working memory errors ( p < 0.05 relative to rats receiving QA without transplants). prior to the first trial on the first day of testing and following the last trial on the last day of testing. Dependent...

Reinstatement in Toddlers and Preschool Children

Reinstatement during this age period and we also want to know how reinstatement can impact event recall in real-world contexts. Because it is likely that in real-world contexts children's reexposure to event information takes the form of viewing photographs or home videos, we have studied how these types of symbolic or representational reminders reinstate children's event memories. This, in turn, requires that we investigate how children understand the representational functions of these media. Our research therefore brings together literatures on memory development, memory reinstatement, and children's understanding of symbolic media. What follows is a discussion of our research program and how it relates to research on the development of event memory and children's understanding of symbolic media. We conclude with, a discussion of our views on the role of representational reminders in the development of children's long-term memory.

Young Childrens Event Recall

Deferred and elicited imitation paradigms have capitalized on children's interest in and ability to imitate modeled actions. In deferred imitation experiments, an experimenter models a unique action or sequence of actions. Children are restricted from producing the action(s) during this initial training period. After a time delay, children are then encouraged to produce the target action(s). Because children only observe actions, but do not perform any actions themselves during the initial exposure to the event, their subsequent imitation of the actions is considered a form of explicit, declarative memory as opposed to implicit, procedural memory which is the result of practice (Bauer, 2002). Studies using the deferred imitation methodology have shown that infants as young as 6 months showed deferred imitation of actions after a 24-hour delay (Collie & Hayne, 1999) and those infants from 9 to 14 months can remember single actions and two-step action sequences for 1-2 days...

Reminders Symbolic Understanding And Memory Development

Children's developing understanding of the representational functions of symbolic media may also contribute to reminder effectiveness in young children. For example, photographs were not effective reminders for children at 18 months, but evidence of reinstatement with photographs was found at 24 months. Even greater memory enhancement with photograph reminders was evident at 30 months. The amount of information included in the photographs as compared to videos cannot wholly account for these findings reinstatement occurred with 18-month-olds when they viewed videos of objects without action information which is similar to the kind of event information shown in photographs. Thus, with increasing age and experience, children may be reminded of events with increasingly more abstract reminders.

Cannabinoid Receptor Antagonists

There are several reports that SR141716A produces effects that are opposite in direction to those produced by cannabinoid receptor agonists (cf. Sections 5 and 6). More specifically, when administered alone, SR141716A has been found to produce hyperkinesia in mice (Compton et al., 1996), provoke signs of increased arousal in rats (Santucci et al., 1996), improve social short-term memory in rats and mice (Terranova et al., 1996), augment cyclic AMP production in cells transfected with cannabinoid receptors (Felder et al., 1995), increase the amplitude of electrically-evoked contractions of isolated tissue preparations (Coutts et al., 1995 Coutts and Pertwee, 1996 Pertwee and Fernando, 1996 Pertwee et al., 1996b) and enhance electrically-evoked neurotransmitter release in rat hippocampal slices (acetylcholine), the myenteric plexus of guinea-pig small intestine (acetylcholine) and guinea-pig retinal discs (noradrenaline and dopamine) (Coutts and Pertwee, 1996, 1997 Gifford and Ashby,...

Systems for Classifying Types of Memory

Have identified working memory and distinguished it from associative memory. Working memory is what we use for information that we may only want to keep for a short period of time, while we use it to perform some particular piece of work.The classic example is hearing or reading a telephone number. We keep it briefly, dial the number, and talk to the person we have called. By the time we hang up the phone, the memory for the number has been erased. Sometimes we keep things in working memory and refer to them as we do a task (i.e., use them to perform work). For example, performing a long string of calculations in our head is a working memory task (e.g., add five and seven, multiply by eight, and divide by three). Associative memory is contrasted with working memory because it is composed of more long-term stores of associations that we refer to when we remember (e.g., who discovered America, or the color of our father's hair when he was a young man).Yet another contrasting way of...

Recovering Animals From Slides

Locate the animal you want to recover under microscope. Go to the lowest magnification (x10 usually) and memorize the surroundings of the animal. 3. Take the slide to a stereo microscope (avoid moving the microscope stage when removing the slide from the microscope). Try to locate the desired animal under low magnification using the memorized landmarks. Be aware that certain microscopes might display a mirror image or might show an upside-down image of your slide. If you cannot find your animal, go back to the microscope. If you did not move the stage the desired animal should still be in the center of the field of view.

Reviewing Client Problems

When questioning clients about problems, it is crucial to keep DSM-IV-TR diagnostic criteria in the forefront of your mind. Unfortunately, few of us have a memory that allows for instant recall of diagnostic criteria. We recommend that you design checklists to aid in recalling specific DSM-IV-TR diagnostic criteria. Using homemade diagnostic checklists can help you become familiar with key diagnostic criteria, without necessarily committing them to memory. This simple procedure relieves you of the burden of memorizing 943 pages of diagnostic information.

The Physiological Importance Of Creb

The study of the calcium activation of CREB-mediated gene expression bears considerable neuro-physiological relevance. CREB seems to have an important role in the establishment of long-term memory in a variety of organisms (26). Genetic and molecular studies of learning paradigms in the marine snail Aplysia californica and the fruit fly Drosophila melanogaster have shown that modulating CREB levels or affecting CREB-dependent transcription severely affects the long-term, protein synthesis-dependent phase of the learning paradigm studied (see 26, and references therein). In the mammalian central nervous system, CREB was also found to play a role in information storage. The intrahippocampal perfusion of antisense oligonucleotides designed to bind and trigger degradation of CREB mRNA achieved a transient decrease in CREB levels in the hippocampus, an area of the brain needed for certain spatial memory tasks. This strategy blocked the animal's long-term memory of these spatial tasks...

Emotion Perception And Attention

The results from the visual search task suggest that the underlying at-tentional mechanisms responsible for detecting threatening stimuli are intact in older adults. The dot probe task suggests that older adults with sufficient time will direct attention away from negative stimuli. Negative information shows the same detection advantage in both age groups, but older adults may subsequently focus cognitive resources on denying it access to working memory.

Mapping Extraversion In The Brain Deconstruction And Reduction

Figure depicting different levels of analysis in the deconstruction of personality into narrowly defined psychological domains. The illustration of the molecular level is courtesy of Juergen Suehnel at the Jena Image Library of Biological Macromolecules (jsuehnel imb-jena.de) the molecular structure of adenosine monophosphate is depicted. Names in the row corresponding to the behavioral level of analysis correspond to various cognitive test paradigms such as perception of ambiguously morphed faces, the N-Back working memory tasks, or memory tasks using priming methods or emotional stimuli. Names in the row corresponding to the neural systems level of analysis correspond to the following brain structures Inf Par Lob, inferior parietal lobule FFA, fusiform face area PFC, prefrontal cortex. Names in the row corresponding to the molecular level of analysis correspond to gene polymorphisms known to be associated with individual differences in emotion or personality. FIGURE 5.1....

A set of themes connects the concepts of hiology

No matter what brings you to biology, you will find the study of life to be endlessly challenging and uplifting. But this ever-expanding subject can also be a bit intimidating, even to professional biologists. How, then, can beginning students develop a coherent view of life instead of hopelessly trying to memorize the details of a subject that is now far too big to memorize One approach is to fit the many things you learn into a set of themes that pervade all of biology ways o1' thinking about life that will still apply decades from now, when much of the specific information fossilized in any textbook will be obsolete. Table 1.1 outlines a number of bro,.* themes you will recognize from this first chapter of Biology. These unifying themes will reemerge throughout the book to provide touchstones as you explore life and begin asking important questions of your own.

Longterm Memory Before Age Three

Current perspectives acknowledge the infant as a creature prepared from birth to begin processing and organizing incoming information in meaningful ways (e.g., Mandler, 1992 Bauer, Wiebe, Carver, Waters, & Nelson, 2003). In stark contrast, early developmental theorists perceived the capacity of infants to make sense of the environment and to meaningfully encode events as quite impoverished (James, 1950 Mandler, 1992). From this standpoint, early experiences would have little chance of enduring in memory for later conscious retrieval. Thus, most early work on infant memory development focused exclusively on short-term processes, with retention intervals under several minutes (Bornstein & Sigman, 1986 McCall, 1979 Werner & Perlmutter, 1979). Modern methodologies created for the study of infants and toddlers have revealed relatively more sophisticated cognition during these early periods, and have inspired researchers to rethink the potential for early long-term memory (e.g.,...

Experimental and Theoretical Tools for Studying CaMKII Function

Coomber 1998 Kubota 1999 Zhabotinsky 2000 Kubota and Bower 2001 Kikuchi et al. 2003 Hund and Rudy 2004). Early modeling work concluded that CaMKII in postsynaptic densities could theoretically store information in a stable manner required for long-term memory (Lisman 1985 Lisman and Goldring 1988). Hanson and colleagues later developed a set of differential equations describing CaMKII activity in response to a train of square-pulse calcium signals (Hanson et al. 1994). Since then, more advanced state-based models of CaMKII activity have been developed. Notably, Zhabotinsky has used one such model to examine the role of phosphatases in regulating CaMKII activity (Zhabotinsky 2000). Recently, we have incorporated CaMKII and its participation in rate-dependent cellular processes into a mathematical model of the canine epicardial action potential (Hund and Rudy 2004 Fig. 2). Whole-cell cardiac myocyte models have been used successfully to study myocardial ischemia (Shaw and Rudy 1997...

CaMKII Function in Neurons

Known as LTP and thought to underlie some forms of memory (see reviews Bliss and Collingridge 1993 Lynch 2004). It is now generally accepted that CaMKII activation in postsynaptic densities is important for LTP induction (Malenka et al. 1989 Malinow et al. 1989 Silva et al. 1992a,b Fukunaga et al. 1993 Pettit et al. 1994 Lledo et al. 1995). Early modeling studies concluded that the switch-like nature of CaMKII could theoretically encode long-term memory (Lisman and Goldring 1988). Experimental evidence for this first came from the fact that CaMKII inhibitors impair LTP in CA1 hippocampal cells (Malenka et al. 1989 Malinow et al. 1989). Subsequently, it was found that both LTP and spatial learning are severely impaired in mutant mice lacking CaMKIIa (Silva et al. 1992a,b). In fact, eliminating autophosphorylation by point mutation is enough to eliminate spatial learning (Cho et al. 1998 Giese et al. 1998).

Attentional Control

As previously noted, attentional control (or executive control) refers to the ability to modulate and coordinate multiple component processes in an effort to maintain focus on task-relevant information in the presence of distraction. There is presently a large literature regarding the nature and potential numerosity of such attentional control mechanisms 10-12 . For present purposes, the discussion is restricted to several of the most commonly studied attentional control processes in which the effects of aging have been addressed using functional neuroimaging methods. These include working memory (sometimes more specifically referred to as updating), inhibition, and task switching (or shifting). Numerous studies have described age-related declines in a variety of control processes in normal elderly populations 10, 12 . In large part because normal older adults exhibit deficits in attentional control processes that are similar to those displayed by patients with frontal lesions,...

Variability Within Normal Aging

One important, yet currently unaddressed, issue that will have a large bearing on the understanding of individual differences among older adults involves the reliability of functional activations within individuals across time and how this reliability differs among age groups. Several studies have examined the reliability of functional imaging methods in younger adults, generally finding extremely high levels of intra-individual stability 145-147 . However, the effect of aging on the reliability of functional responses remains unknown. Preliminary evidence from a study of repeated measurements of younger and older adults performing a working memory task indicates that both groups exhibit high levels of reliability in functional imaging measures, with older adults displaying reliability that is as high or higher than in younger adults 148 . If these results are confirmed, then individual differences observed in the functional activation of older adults are likely the result of...

Restriction and PB Therapy

The new concept bears the advantage that patients do not have to memorize the phosphorus content of each individual food component, but only the PU value for a limited number of food groups. After eye-estimating the PU content of a meal, the patient self-adjusts the PB dose according to a PB PU ratio prescribed by the nephrolo-gist. After introducing the PEP concept to the patient, the PB PU ratio is titrated to the patient's individual needs by repeatedly measuring predialysis serum phosphate levels and re-adjusting the PB PU ratio until phosphate targets have been achieved. This new concept moves away from strict dietary phosphorus restriction towards a more adequate dosing of PBs. It allows patients to maintain an adequate dietary protein intake with a more liberal diet while at the same time reducing the risk of developing hyperphosphatemia. Diet-related hyperphosphatemia can be prevented by adequate PB dosing. PEP (www.pep-ernaehrungsprogramm.de) is the first approach applying...

Complications of Alcohol Withdrawal

Wernicke's encephalopathy is an acute, potentially reversible neurologic disorder that is believed to result from a deficiency of thiamine and is often secondary to chronic alcohol abuse. Features include disturbance of consciousness (ranging from mild confusion to coma), ophthalmoplegia, nystagmus, and ataxia. The disorder has a high mortality and can lead to death within 24 hours. If untreated, it can progress to Korsakoff's psychosis. This is a chronic condition that usually presents as impairment of short-term memory with inability to learn new information and compensatory confabulation. Korsakoff's psychosis probably represents irreversible brain damage secondary to the combined toxic-ity of alcohol and metabolic derangement resulting from thiamine deficiency.

Alcohol and Fitness for Interview

Nonetheless, the effect alcohol can have on short-term memory should be remembered when advising the police on fitness. Research suggests that moderate quantities of alcohol impair the process of forming new memories (67). Deterioration in performance of a task assessing short-term memory occurred at blood alcohol levels of 70 mg 100 mL in one study (68), and a significant impairment of eyewitness memory has been demonstrated at average blood alcohol levels of 100 mg 100 mL (69). When suspects mistrust their own memory of events, they are at increased risk of providing coerced-inter-nalized false confessions (52).

Historical Context

Troconvulsive therapy (ECT), which is also prominently featured in Cuckoo's Nest, has proved a valuable psychiatric treatment for mental illness. In 1938, after an earlier scientist observed that schizophrenics seemed symptom-free following seizures, Italian scientists Cereletti and Bini devised electroshock therapy as an efficient way to manage uncontrollable patients. Today, a severely depressed patient receiving ECT, administered in a series of treatments, has an intravenous relaxant administered and a mouth guard inserted before an anesthetic renders him unconscious. The airway is protected, and electrodes are connected with conducting jelly on the temples. Electric current comparable to a 60-watt bulb shoots through the brain causing a 20-second grand-mal seizure. The patient wakes about 30 minutes later, confused and disoriented, with a headache and short-term memory loss. In essence, ECT helps disturbed patients regain the control necessary to enter into a therapeutic...

Laboratory studies of symptoms in CFS

A further contributing factor may be that CFS sufferers have a bias to monitor somatic-related information. As we have seen, heightened attention to the body increases symptom reports even in healthy people. It may be that patients with CFS have a propensity to focus on bodily sensations, which contributes to both their high symptom reports and a tendency to misinterpret bodily sensations as signs of illness or harm. Such an attention bias would help to explain the objective difficulties found when they are asked to complete tasks that require greater levels of attention. If an increased amount of CFS patients' attention is inadvertently focussed on their bodily symptoms, it is reasonable to assume that less attention will be available for other tasks. Impaired attentional processes will in turn affect the speed of processing and working memory functions. The dramatic way in which this cognitive difficulty is then interpreted may be particularly pathogenic. For instance, one CFS...

Arterial bifurcation and flow distribution

These simple models can help in memorizing the effects of the most important factors that determine velocity and pulsatility of flow. Flow models that are invoked to explain actual flow findings should be corrected with respect to patient condition, vital signs, medications and waveform morphology.

Neuropsychology Of Aged Rodents

T-maze in which egocentric (body-turn) and visual cue-guided strategies were also able to support accurate discrimination behavior. Subsequent reports indicated that aged rats used different behavioral strategies in the Morris and T-water mazes, and detection of age-related spatial learning deficits depended on the task used and the strategies employed 30 . In particular, these authors noted that the acquisition of spatial tasks using egocentric strategies was unimpaired in aged rats. Complementary observations were reported by Nicolle et al. 31 in aged mice using a cue-competition paradigm in the water maze. In this task, mice learn to swim to a visible platform in a fixed location. Probe trials are given in which the visible platform is moved to a different location in the maze mice either swim toward the visible platform in its new location (a cue strategy) or swim toward its previous location first (a place strategy). The prevalence of a cue strategy increased with age, with...


It is now well known that one generally experiences relatively mild changes in cognitive abilities with age, particularly with abilities such as short-term memory, executive functions, and confrontation naming 1 . However, a select group of these successfully aged individuals evidence virtually no change in their cognitive abilities with age, even into the eleventh decade of life 2 . Such individuals have often been referred to as examples of pristine successful aging. At the other end of the continuum, a large percentage of people are known to develop marked cognitive decline with age, characterized by a dementia state, with a majority of those developing Alzheimer's disease (AD). These individuals fall into the category of unsuccessful aging. In recent years, however, clinical researchers have characterized a group as individuals who, with advancing age, show a moderate impairment in one or more cognitive domains that affects the ability to carry out activities of daily living but...


Irrespective of current human practice, in the future it is impossible not to envisage high-throughput machines analysing routine samples of biological specimens. Widespread use of automation will not be immune from the introduction of human biases into the results. Errors will be due in part to the inadequacies of the machines and software themselves, which, after all, are both human constructs, but a proportion will be due to incorrect expert-labelled training data. To improve the entire process, these errors must be minimized and also quantified. It is possible that error rates as high as 25 per cent will be the norm for large-scale analysis. These error rates may well be similar to current and historical human errors in field sample analysis. Some of these errors will be due to human factors, short-term memory, fatigue, monotony and biases. Some errors will be due to a lack of consensus on the label given to difficult taxonomic specimens and species.


One way children are reminded of a past event is by physically repeating all or part of the event at another time. This procedure, reenactment, is similar to multiple training trials in that children physically reproduce some or all of the actions they learned in the past. We consider reenactment to be the most complete and concrete type of reminder. Not only do children actively participate in their retraining, but they interact directly with the experimenter, providing additional context for their experience. Our reenactment research began with an investigation of its effects on 18-month-olds' long-term memory (Hudson & Sheffield, 1998). The reenactment procedure was conducted in the following manner During the training session, children visited our laboratory playroom and were shown how to perform eight novel, two-step activities using an elicited imitation procedure. The activities were designed to be interesting for 18-month-olds, but not to be things that they could discover...


This chapter presents an overview of nuclear gene expression and its regulation in neurons. The major steps involved in these processes are (1) relaxation of the chromatin structure to make DNA accessible to transcription regulatory machinery (2) binding of the transcription factors, proteins capable to interact with specific DNA sequences as well as with other proteins to regulate the transcription (3) activation of RNA polymerase, an enzyme catalyzing the transcription itself (4) transcription, resulting in formation (elongation) of a primary transcript (5) capping (addition of 7methyloGuanine) to the 5' end of the nascent transcript (6) splicing, i.e., removal of the introns from the primary transcript (7) polyadenylation (addition of more than a hundred of adenine residues to the 3' end of the transcript) (8) export of the mRNA from the nucleus to the cytoplasm (9) specific localization of the mRNA to defined cell compartments, such as dendrites (10) survival of the mRNAs...

Acetylation Levels

The CREB binding protein (CBP) is one of most extensively characterized coactivator proteins. CBP was first identified through its ability to link the phosphorylated form of CREB by the cyclic AMP protein kinase (PKA) to components of the basal transcriptional machinery, including TFIIB, TATA-binding protein, and the RNA polymerase II holoenzyme complex. CBP is highly related to p300, and CBP and p300 are considered to be functional homologues, although a few differences in their activities have been reported (Kawasaki et al., 1998 Kalkhoven 2004). CBP and p300 associate with a wide variety of transcriptional activators in addition to CREB, suggesting that each may serve as a transcriptional integrator of different signaling cascades (reviewed in references (reviewed in Vo and Goodman 2001). CBP and p300 have also been proposed to mediate transcriptional activation via intrinsic and associated HAT activity. CBP's HAT activity has been identified notably as a...

The Salerno Regimen

The new universities fed the early medieval 'Romanesque' enthusiasm for literacy, culture, and self-improvement. The message of the health-conscious regimen was strongly promoted by the new university-trained medici, supported by Romano-Islamic classical scholarship such as that of the comprehensive, easy-to-memorize, four-volume Canon of Medicine by Ibn Sina (Avicenna 980-1037). The physicians were eager to get classical preventive medicine on board alongside their other 'cures', and profited well from it their personally tailored regimens and consilia (letters of advice) were available to anyone who could afford them. Throughout Europe there were growing numbers of manuscript tracts and volumes for general readers on all subjects religious and secular and roughly 3 to 4 per cent of these were medical works.16 Evidently one had to be 'wise in science' at court. Encyclopedic 'books of secrets' (such as the famous Aristotle's Secrets) could be read or memorized in short bursts, as well...

Cognitive Aging

According to the frontal aging hypothesis, age-related cognitive decline is driven by deterioration of the frontal brain areas, notably the prefrontal cortex (PFC) (for reviews, see Greenwood, 2000 West, 1996). Indeed, neural declines in volume are found to be greatest in the frontal lobes and smallest in the sensory cortices (for reviews, see Hedden & Gabrieli, 2004 Raz, 2000 Tisserand & Jolles, 2003). Functions involving the type of cognitive control mediated by PFC regions are particularly likely to decline with age. For example, impairments are seen in selective activation of goal-relevant information, episodic memory, prospective memory, and working memory (Hasher, Zacks, & May, 1999 Hedden & Gabrieli, 2004 Prull et al., 2000 Raz, 2000 West, 1996). Conversely, autobiographical and automatic memory processes, performance on theory-of-mind tasks, and vocabulary and semantic knowledge are all relatively stable across the adult life span, at least until the seventh or...

Emotion Research

There is little research examining the impact of age on the separate subre-gions of the PFC. Some evidence suggests that the orbito-frontal cortex and other areas associated with the regulation of emotion and social behavior may exhibit less age-related decline than other areas of the PFC do (Salat, Kaye, & Janowsky, 2001). In addition, in a recent study examining age differences on tests sensitive to dorsolateral PFC dysfunction (executive function and working memory) and ventromedial PFC dysfunction (emotion and social decision making), age-related performance differences occurred on all of the tasks dependent on the dorsolateral PFC, but did not occur on the majority of tasks dependent on the ventromedial PFC (MacPherson et al., 2002 but see Lamar & Resnick, 2004). Thus research examining the effects of aging on affective brain systems is consistent with behavioral findings showing emotional functioning to be an area of resiliency and even improvement over time (for reviews,...

Emotion Regulation

Previously trained in both kinds of strategies viewed a series of negative images. Prior to each image, they were instructed to enhance or diminish their emotional response, or just to look at the image. In comparison to just look trials, both up-regulation and down-regulation trials showed increased activation in left lateral PFC regions involved in working memory and response selection, along with increased activation in the dorsomedial PFC. Increased activation of the ACC also was observed. Interestingly, activation in the amygdala was modulated, such that enhancing emotional responses resulted in increased activation and diminishing emotional responses resulted in decreased activation in this structure.

Memory And Emotion

Evidence for the role of the amygdala in the modulation of memory comes from patients with bilateral amygdala damage, who have intact memory for nonemotional stimuli, but show specific impairments in memory for both visual and verbal emotional material in comparison to controls without brain damage (Cahill et al., 1995 Markowitsch et al., 1994). Impairments in memory for emotional material have also been observed in patients with unilateral amygdala damage (Adolphs, Tranel, & Denberg, 2000). In patients diagnosed with Alzheimer's disease, which is known to result in a dramatic reduction in amygdala volume (Callen, Black, Gao, Caldwell, & Szalai, 2001), there is evidence that the memory enhancement for emotional material typically found in healthy adults is absent for both verbal and pictorial information (Abrisqueta-Gomez, Bueno, Oliviera, & Bertolucci, 2002 Kensinger, Anderson, Growdon, & Corkin, 2004 Kensinger, Brierly, Medford, Growdon, & Corkin, 2002). The medial...

Brain Stem

Brain Stem Motor Nuclei Images

Memorize the 12 cranial nerves and their functions. Ribald mnemonics will help. You must know the individual cranial nerves and their functions on instant recall. 2. Next, memorize the chart in figure 19 which includes the same information as above rearranged differently. Unlike the spinal nerves, which are mixed nerves containing motor and sensory components, the cranial nerves are much simpler. Three of them are purely sensory, 5 are purely motor and only four are mixed. The term somatovisceral will be explained later.


Studies of hypnosis as a treatment modality for children's pain pervade the literature from the 1980s (60). During hypnotic states, modification or enhancement of perceptions and sensations may occur (61). Hypnosis is often recommended as a particularly appropriate intervention for children, who are generally more susceptible to hypnosis than adults (62), possibly because of their greater readiness to immerse themselves in fantasy (63). Although the exact mechanism of action is not well understood, work with neuroimaging techniques showed that hypnosis is associated with significant increases in occipital regional cerebral blood flow and delta electroencephalographic activity, reflecting the alteration of consciousness associated with decreased arousal and potential facilitation of visual imagery (64,65). The observed frontal increases in regional cerebral blood flow associated with suggestions for altered perception may therefore reflect the verbal mediation of suggestions, working...


Technological cognition will be inherently limited without the other functionalities that brains provide (see Appendix Section A.1). Further limitations arise because of the lack of on-line memory formation mechanisms (short-term, medium-term, and long-term memory processes) and the lack of a capability for goal-driven delayed reinforcement learning of thought and movement procedures (see Section 3.6). Yet, despite these limitations, there are probably many high-value early applications of pure cognition that will be possible. Pure cognition is the focus of this chapter.


The neural correlates of cognitive performance during normal aging are complex and varied. Older adults exhibit declines not only in memory performance, but also in several processes related to attentional control, including working memory, inhibition, and task switching. Normal aging appears primarily associated with changes in the prefrontal cortex and a set of related neural networks, including frontal-parietal and frontal-striatal networks. Age-related changes in volume, dopaminergic neurotransmission, and functional activation within these systems appear to underlie, to a large extent, the behavioral differences observed during normal aging. Memory deficits in normal older adults may be attributable to failures of connections between these prefrontal networks and the medial temporal systems that underlie memory function. In contrast, pathological aging processes associated with MCI and Alzheimer's disease appear to directly and severely affect medial temporal lobe memory systems,...

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