Knockout Mice In Cardiology

NME in cardiology have been directed toward hypertension, blood coagulation and thrombosis. Knock-out of either angiotensin-converting enzyme (ACE) or the angiotensin receptor ATj results in significant decreases in resting blood pressure in mice. These KO mice be used as a milestone for complete blockade and compared to the effect of ACE inhibitors and ATj receptor inhibitors (34). KO of the ADP receptor and Factor X have helped to identify the mechanism of action of anti-thrombotic drugs.

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