Knockout Mice In Cardiology

NME in cardiology have been directed toward hypertension, blood coagulation and thrombosis. Knock-out of either angiotensin-converting enzyme (ACE) or the angiotensin receptor ATj results in significant decreases in resting blood pressure in mice. These KO mice be used as a milestone for complete blockade and compared to the effect of ACE inhibitors and ATj receptor inhibitors (34). KO of the ADP receptor and Factor X have helped to identify the mechanism of action of anti-thrombotic drugs.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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