Hematopoietic Growth Factors

The formation and differentiation of hematopoietic cells to give rise to mature blood cells require a series of growth factors. These growth factors are mainly single-chain polypeptides and can be produced by microbial systems. However, cell culture technology can offer advantages when the molecule is complicated by glycosylation and when the native form of the molecule is required for therapy.

Erythropoietin (EPO) is a hormone that controls the maturation of red blood cells and it is used for clinical applications in anemia. Recombinant EPO was genetically engineered in CHO cells and the product was launched in 1989 under the names of Epogen® (Amgen), Procrit® (Johnson and Johnson), and Eprex® (Johnson and Johnson). EPO was launched in 1990 in Europe and Japan under the names of Epogin® and Recormon®.

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