OLinked Oligosaccharides

Protein O-glycosylation is more common in secreted and membrane-associated proteins (22). O-linked oligosaccharides are attached to the protein by an O-glycosidic bond at either a serine or a threonine R-group. No consensus sequence for O-glyco-sylation appears to exist, since site-directed mutagenesis does not influence site-specific glycosylation (18). O-glycosylated proteins are relatively resistant to proteases (23). O-oligosaccharides are typical smaller and less complex than N-oligosaccharides. The attached O-oligosaccharide can vary from 1 to 20 sugar residues. Unlike in N-oligosaccharides, the core structure is not conserved. There are at least seven different core structures, with the five most common shown in Fig. 3. O-oligosaccharides often contain GlcNAc, GalNAc, and galactose.

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