Other Products

There are several other products from cell culture technology that must be mentioned here. Recombinant activated protein C is a major product marketed by Eli Lily, approved in 2001 for the treatment of severe sepsis. HEK 293 cells are used for the production of activated protein C.

Follicle stimulating hormone is used for the treatment of infertility. FollistimĀ® (Organon) and GonalĀ® (Serano) obtained approval in 1997 and 1998, respectively, for stimulation of ovulation during assisted reproduction. CHO cells are used for the production of both products.

Soluble TNF receptor, EmbrelĀ®, is used as a fusion protein TNFR (conjugated to antibody-Fc) for the treatment of moderate to severe active rheumatoid arthritis. Following initial approval in 1998, the product was later approved for juvenile rheumatoid arthritis (1999), for disease modification of active rheumatoid arthritis, and for psoriatic arthritis (January 2002). Embrel is produced from CHO cells.

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