Pyridoacridine Alkaloids

Mass Spectra Alkaloid Salt

Marine pyridoacridine alkaloids have been the subject of intense study due to their significant biological activities.4-13 Over 75 pyridoacridine alkaloids have been isolated and characterized from marine source and it is expected that more of these alkaloids will be isolated in future. Almost all known pyridoacridine alkaloids are reported to have significant cytotoxicity. The compounds of this group also display several specific biological properties, such as inhibition to topoisomerase...

Bioactive Marine Peptides 31 Marine Algae

Bioactive Peptides And Origin

Certain varieties of Lyngbya majuscula,19-27 a toxic marine blue-green alga found in warm water have been implicated as the causative agents of Swimmer's'itch, a form of contact dermatitis. Lyngbyatoxin-A ( 1)28-5 was isolated from L. majuscula and the gross structure was determined as the prenylated cyclic dipeptide. The configuration at the C-14 quaternary carbon in (1) was subsequently shown to be (R) by degradation of (1) to dimethyl 2(S)-2-ethyl-2-methylglutarate.36 Lyngbyatoxin-A (1)...