Biological Toxicological and Clinical Evaluation


The chapter deals with the methods of biological, toxicological and clinical evaluations of the extracts and/or pure compounds from marine organisms. The screening models for evaluation of antibacterial, antifungal, antileishmanial, antihookworms, antitapeworms, antimalarial, antiviral and anticancer activities and problems of screening have been discussed. Besides, the methods of evaluation of analgesic, antiallergic, antiarrhythmic, antithrombotic, hypolipidaemic, hypoglycemic, hypotensive, antihypertensive, diuretic, adaptogenic, immunomodulatory, hepatoprotective, choleretic and anticholestatic activities have been described. Finally, evaluation of acute and regulatory toxicity and studies needed for clinical trials have also been discussed.

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