Type 2 Diabetes Mellitus

Disease Process Diabetes Mellitus

The glucose homeostasis dysregulation in T2DM is mainly due to a combination of two physiological defects impaired insulin secretion and reduced peripheral and hepatic insulin sensitivity 18 (Fig. 12.1). The development of T2DM is a gradual process, and the relative roles of the two defects in the etiology of the disease remain controversial. However, it is now generally agreed that overt diabetes arises when beta-cells can no longer compensate for the insulin resistance. In the following,...

Type 1 Diabetes Mellitus

T1DM results from an absolute deficiency of insulin due to the autoimmunologi-cal attack and destruction of the beta-cells. The present concept of the pathogenesis ofTIDM is mainly based on evidence from studies on the animal models of human T1DM. The diabetes-prone BioBreeding (BB-DP) rat spontaneously develops a diabetic syndrome with characteristics similar to the human T1DM. In the non-obese diabetic mice model (NOD), autoimmune diabetes can be transferred from a diabetic to a non-diabetic...

Hsp60 100 Hsp70 97 Hsp 90 97 Hsv1 263 Hsv2 263 Hugo

- Gene Nomenclature Committee 405 - Mutation Database Initiative 389, 411 human - gene mutation database (HGMD) 393 - genome variation database (HGVbase) 393 - immunodeficiency virus (HIV) 247 Huntington's disease (HD) 336 3-hydroxy-3-methylglutaryl-coenzyme A reductase 50 hypercholesterolemia 49 hyperglycemia 215 hyperlipidemias 40 hyperproinsulinemia 210 hypoglycemia 215 hypothetical protein 289 hypoxia 20 - inducible factor 1 (HIF-1) 83 ICP0 277 ICP27 278 IFNa 78 IgA 42 IGF2 116 IgG 42 IL-2...

Chlamydia trachomatis Immunoproteome

After infection, the presence in the host organism of non-self pathogen structures elicit a polyclonal antibody response. One can characterize such responses by defining the specificity of the antibodies generated in the response. Only a subset of the pathogen proteome elicits antibody responses which are responsible for the 'immunoproteome' i.e. they give rise to antibody responses and bind to these antibodies. With respect to the infected host, a genetic susceptibility may occur, which could...