Type 2 Diabetes Mellitus

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The glucose homeostasis dysregulation in T2DM is mainly due to a combination of two physiological defects: impaired insulin secretion and reduced peripheral and hepatic insulin sensitivity [18] (Fig. 12.1). The development of T2DM is a gradual process, and the relative roles of the two defects in the etiology of the disease remain controversial. However, it is now generally agreed that overt diabetes arises when beta-cells can no longer compensate for the insulin resistance. In the following, impaired insulin secretion and insulin resistance, which are physiologically interconnected will be analyzed in more detail.

Disease Process Diabetes Mellitus

Figure 12.1 Pathophysiology of type 2 diabetes mellitus. T2DM is characterized by two physiological defects: impaired insulin secretion and impaired insulin action (insulin resistance). Whether the primary defect initiating the glucose intolerance resides in the beta-cell or in the peripheral tissues remains con-

troversial. Abnormalities in the four major organ systems involved in glucose homeostasis contribute to the hyperglycemia observed in T2DM. Knowledge of the precise molecular alterations associated with these abnormalities will be of great help for a successful disease prevention and treatment.

Figure 12.1 Pathophysiology of type 2 diabetes mellitus. T2DM is characterized by two physiological defects: impaired insulin secretion and impaired insulin action (insulin resistance). Whether the primary defect initiating the glucose intolerance resides in the beta-cell or in the peripheral tissues remains con-

troversial. Abnormalities in the four major organ systems involved in glucose homeostasis contribute to the hyperglycemia observed in T2DM. Knowledge of the precise molecular alterations associated with these abnormalities will be of great help for a successful disease prevention and treatment.

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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