Derivatization Reactions for Gas Chromatographic Determination of Amines

Reagent

Amine Type

Acylation

Trifluoroacetic anhydride (TFA) Trichloroacetyl chloride (TCA) N-Methylbis(trifluoroacetamide) (MBTFA) Trifluoroacetic anhydride and diethylether (1:1) (TFA) Heptafluorobutyric anhydride (HFBA) Pentafluoropropionic anhydride (PFPA)

Silylation

N,0-Bis(trimethyl silyl)trifluoroacetamide (BSTFA) A,-Methyl-A,-(ieri-butyldimethylsilyl)acetamide (MTBSTFA)

Dinitrophenylation

2,4-Dinitrofluorobenzene (DNFB) 2,4-Dinitrobenzenesulphonic acid (DNBS)

Formamide-sodium borohydride N-Dimethylaminimethylene (DMAM)

Permethylation

Schiff base formation

Furfural P

Pentafluorobenzaldehyde (PFBA) P, Al

Dimethylformamide dimethyl acetal (DMFDMA) P

Ethyl chloroformate (ECF) Isobutyl chloroformate (IBCF)

Benzenesulphonyl chloride (BSC) p-Toluenesulphonyl chloride (TSC)

Dimethylthiophosphoryl chloride (DMTPC) Diethylthiophosphoryl chloride (DETPC) A'-Diethylthiophosphoryl (DETP) Diethyl chlorothiophosphate (DECTP)

p-Nitrophenyl trifluoroacetate

Carbamate formation

Sulphonamide formation

Phosphoamide formation

Halogenation

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